ye7 login 100 percent of evaluable patients for minimal residual disease (MRD) testing achieved MRD negativity in MajesTEC-5 as induction therapy and MajesTEC-4 as maintenance therapy SAN DIEGO , Dec. 8, 2024 /PRNewswire/ -- Johnson & Johnson (NYSE:JNJ) today announced new frontline data featuring TECVAYLI ® (teclistamab-cqyv) from two investigational studies in patients with newly diagnosed multiple myeloma (NDMM) in induction and maintenance settings. The MajesTEC-5 ( Abstract #493 ) and MajesTEC-4 ( Abstract #494 ) studies establish the potential of TECVAYLI ® for use in newly diagnosed patients, with promising efficacy and a tolerable safety profile. These data were highlighted as oral presentations at the 2024 American Society of Hematology (ASH) Annual Meeting. 1,2 Forty-nine patients with transplant-eligible NDMM were treated with TECVAYLI ® in combination with DARZALEX FASPRO ® (daratumumab and hyaluronidase-fihj), lenalidomide and dexamethasone (Tec-DRd) or DARZALEX FASPRO ® , bortezomib, lenalidomide and dexamethasone (Tec-DVRd) as induction therapy in the MajesTEC-5 study. 1 All patients who were evaluated for MRD negativity after cycle 3 of induction therapy achieved MRD negativity (10 -5 ) and maintained through cycle 6. 1 "These data from the MajesTEC-5 study build on the growing body of evidence of TECVAYLI combinations that support the potential combinability of TECVAYLI with other effective therapies, demonstrating high rates of MRD-negative responses for evaluable patients with newly diagnosed multiple myeloma," said Rachel Kobos, M.D., Vice President, Oncology Research & Development, Johnson & Johnson Innovative Medicine. "At Johnson & Johnson, our deep expertise and understanding of multiple myeloma has shaped the regimens we're developing, including our bispecific antibodies in new combinations, and we're committed to exploring the full potential of our therapies to improve outcomes for patients." The safety profiles were manageable and consistent with individual safety profiles. 1 No treatment-emergent adverse events (TEAEs) led to study treatment discontinuation or death; cytokine release syndrome (CRS; Grade 1 or 2) occurred in 65 percent of patients. 1 No patients experienced immune effector cell-associated neurotoxicity syndrome (ICANS). 1 Grade 3/4 TEAEs included lymphopenia (43 percent), neutropenia (57 percent) and infections (35 percent). 1 "There remains opportunity to achieve even deeper and more sustained outcomes for a broader patient population in the frontline setting," said Marc S. Raab , M.D., Heidelberg University Hospital, Germany .* "These data reinforce the potential of TECVAYLI when used in earlier lines and show that TECVAYLI can be leveraged to optimize existing standard regimens in combination." Results from the safety run-in of the Phase 3 MajesTEC-4 study highlighted the potential of TECVAYLI ® to be administered as a maintenance therapy following autologous stem cell transplant (ASCT). 2 MajesTEC-4 is the first study to present data on a B-cell maturation antigen (BCMA) bispecific as monotherapy or combination therapy after ASCT. 2 Low rates of non-hematologic Grade 3/4 TEAEs and discontinuation of treatment due to all TEAEs (5.3 percent) were observed. CRS events were all Grade 1/2, mostly occurring during step-up dosing, and ICANS was not observed. Neutropenia and infections were the most common Grade 3/4 TEAEs. 2 Grade 3/4 neutropenia at 6 months showed a decreased trend in cohorts 2 and 3 with less frequent TECVAYLI ® dosing (cohort 1: 94 percent, cohort 2: 63 percent, cohort 3: 47 percent). 2 A similar trend was observed for all-grade infections (cohort 1: 94 percent; cohort 2: 78 percent; cohort 3: 77 percent). 2 All evaluable patients in cohort 1 who underwent MRD assessment after 12 months of therapy were MRD negative, and 100 percent of evaluable patients assessed in cohorts 2 and 3 were also MRD negative at cycle 6. 2 Further analysis of combination therapies will be evaluated in the Phase 3 MajesTEC-7 study, which is currently enrolling. About MajesTEC-5 Study MajesTEC-5 ( NCT05695508 ) is an ongoing, Phase 2 study of teclistamab and talquetamab, evaluating the safety and efficacy of combination regimens in participants with newly diagnosed transplant eligible multiple myeloma. 3 About MajesTEC-4 Study MajesTEC-4 ( NCT05243797 ) is an ongoing, multicenter, randomized, open-label, Phase 3 study of teclistamab in combination with lenalidomide and teclistamab alone versus lenalidomide alone in participants with newly diagnosed multiple myeloma as maintenance therapy following autologous stem cell transplantation. 4 About MajesTEC-7 Study MajesTEC-7 ( NCT05552222 ) is a Phase 3 randomized study comparing teclistamab in combination with daratumumab SC and lenalidomide (Tec-DR) and talquetamab in combination with daratumumab SC and lenalidomide (Tal-DR) versus daratumumab SC, lenalidomide, and dexamethasone (DRd) in participants with newly diagnosed multiple myeloma who are either ineligible or not intended for autologous stem cell transplant as initial therapy. 5 About TECVAYLI ® TECVAYLI ® (teclistamab-cqyv) received approval from the U.S. FDA in October 2022 as an off-the-shelf (or ready-to-use) antibody that is administered as a subcutaneous treatment for adult patients with relapsed or refractory multiple myeloma (RRMM) who have received at least four prior lines of therapy, including a proteasome inhibitor, an immunomodulatory agent and an anti-CD38 antibody. 6 The European Commission (EC) granted TECVAYLI ® conditional marketing authorization (CMA) in August 2022 as monotherapy for the treatment of adult patients with RRMM who have received at least three prior therapies, including a proteasome inhibitor, an immunomodulatory agent and an anti-CD38 antibody, and have demonstrated disease progression since the last therapy. In August 2023 , the EC granted the approval of a Type II variation application for TECVAYLI ® , providing the option for a reduced dosing frequency of 1.5 mg/kg every two weeks in patients who have achieved a complete response (CR) or better for a minimum of six months. TECVAYLI ® is a first-in-class, bispecific T-cell engager antibody therapy that uses innovative science to activate the immune system by binding to the CD3 receptor expressed on the surface of T-cells and to the B-cell maturation antigen (BCMA) expressed on the surface of multiple myeloma cells and some healthy B-lineage cells. In February 2024 , the U.S. FDA approved the supplemental Biologics License Application (sBLA) for TECVAYLI ® for a reduced dosing frequency of 1.5 mg/kg every two weeks (Q2W) in patients with relapsed or refractory multiple myeloma who have achieved and maintained a CR or better for a minimum of six months. For more information, visit www.TECVAYLI.com . About DARZALEX FASPRO ® and DARZALEX ® DARZALEX FASPRO ® (daratumumab and hyaluronidase-fihj) received U.S. FDA approval in May 2020 and is approved for nine indications in multiple myeloma, four of which are for frontline treatment in newly diagnosed patients who are transplant eligible or ineligible. It is the only subcutaneous CD38-directed antibody approved to treat patients with MM. DARZALEX FASPRO ® is co-formulated with recombinant human hyaluronidase PH20, Halozyme's ENHANZE ® drug delivery technology. DARZALEX ® is the first CD38-directed antibody approved to treat multiple myeloma. DARZALEX ® -based regimens have been used in the treatment of more than 585,000 patients worldwide and more than 239,000 patients in the U.S. alone. In August 2012 , Janssen Biotech, Inc. and Genmab A/S entered a worldwide agreement, which granted Janssen an exclusive license to develop, manufacture and commercialize daratumumab. For more information, visit https://www.darzalexhcp.com. About Multiple Myeloma Multiple myeloma is an incurable blood cancer that affects a type of white blood cell called plasma cells, which are found in the bone marrow. 7 In multiple myeloma, these plasma cells proliferate and spread rapidly and replace normal cells in the bone marrow with tumors. 8 Multiple myeloma is the third most common blood cancer worldwide and remains an incurable disease. 9 In 2024, it was estimated that more than 35,000 people will be diagnosed with multiple myeloma in the U.S. and more than 12,000 people would die from the disease. 10 People living with multiple myeloma have a 5-year survival rate of 59.8 percent. 11 While some people diagnosed with multiple myeloma initially have no symptoms, most patients are diagnosed due to symptoms that can include bone fracture or pain, low red blood cell counts, tiredness, high calcium levels and kidney problems or infections. 12,13 TECVAYLI ® IMPORTANT SAFETY INFORMATION WARNING: CYTOKINE RELEASE SYNDROME and NEUROLOGIC TOXICITY including IMMUNE EFFECTOR CELL- ASSOCIATED NEUROTOXICITY SYNDROME Cytokine release syndrome (CRS), including life-threatening or fatal reactions, can occur in patients receiving TECVAYLI ® . Initiate treatment with TECVAYLI ® step-up dosing schedule to reduce risk of CRS. Withhold TECVAYLI ® until CRS resolves or permanently discontinue based on severity. Neurologic toxicity, including Immune Effector Cell-Associated Neurotoxicity Syndrome (ICANS) and serious and life- threatening reactions, can occur in patients receiving TECVAYLI ® . Monitor patients for signs or symptoms of neurologic toxicity, including ICANS, during treatment. Withhold TECVAYLI ® until neurologic toxicity resolves or permanently discontinue based on severity. TECVAYLI ® is available only through a restricted program called the TECVAYLI ® and TALVEY ® Risk Evaluation and Mitigation Strategy (REMS). INDICATION AND USAGE TECVAYLI ® (teclistamab-cqyv) is a bispecific B-cell maturation antigen (BCMA)-directed CD3 T-cell engager indicated for the treatment of adult patients with relapsed or refractory multiple myeloma who have received at least four prior lines of therapy, including a proteasome inhibitor, an immunomodulatory agent and an anti-CD38 monoclonal antibody. This indication is approved under accelerated approval based on response rate. Continued approval for this indication may be contingent upon verification and description of clinical benefit in confirmatory trial(s). WARNINGS AND PRECAUTIONS Cytokine Release Syndrome - TECVAYLI ® can cause cytokine release syndrome (CRS), including life-threatening or fatal reactions. In the clinical trial, CRS occurred in 72% of patients who received TECVAYLI ® at the recommended dose, with Grade 1 CRS occurring in 50% of patients, Grade 2 in 21%, and Grade 3 in 0.6%. Recurrent CRS occurred in 33% of patients. Most patients experienced CRS following step-up dose 1 (42%), step-up dose 2 (35%), or the initial treatment dose (24%). Less than 3% of patients developed first occurrence of CRS following subsequent doses of TECVAYLI ® . The median time to onset of CRS was 2 (range: 1 to 6) days after the most recent dose with a median duration of 2 (range: 1 to 9) days. Clinical signs and symptoms of CRS included, but were not limited to, fever, hypoxia, chills, hypotension, sinus tachycardia, headache, and elevated liver enzymes (aspartate aminotransferase and alanine aminotransferase elevation). Initiate therapy according to TECVAYLI ® step-up dosing schedule to reduce risk of CRS. Administer pretreatment medications to reduce risk of CRS and monitor patients following administration of TECVAYLI ® accordingly. At the first sign of CRS, immediately evaluate patient for hospitalization. Administer supportive care based on severity and consider further management per current practice guidelines. Withhold or permanently discontinue TECVAYLI ® based on severity. TECVAYLI ® is available only through a restricted program under a REMS. Neurologic Toxicity including ICANS - TECVAYLI ® can cause serious or life-threatening neurologic toxicity, including Immune Effector Cell-Associated Neurotoxicity Syndrome (ICANS). In the clinical trial, neurologic toxicity occurred in 57% of patients who received TECVAYLI ® at the recommended dose, with Grade 3 or 4 neurologic toxicity occurring in 2.4% of patients. The most frequent neurologic toxicities were headache (25%), motor dysfunction (16%), sensory neuropathy (15%), and encephalopathy (13%). With longer follow-up, Grade 4 seizure and fatal Guillain-Barré syndrome (one patient each) occurred in patients who received TECVAYLI ® . In the clinical trial, ICANS was reported in 6% of patients who received TECVAYLI ® at the recommended dose. Recurrent ICANS occurred in 1.8% of patients. Most patients experienced ICANS following step-up dose 1 (1.2%), step-up dose 2 (0.6%), or the initial treatment dose (1.8%). Less than 3% of patients developed first occurrence of ICANS following subsequent doses of TECVAYLI ® . The median time to onset of ICANS was 4 (range: 2 to 8) days after the most recent dose with a median duration of 3 (range: 1 to 20) days. The most frequent clinical manifestations of ICANS reported were confusional state and dysgraphia. The onset of ICANS can be concurrent with CRS, following resolution of CRS, or in the absence of CRS. Monitor patients for signs and symptoms of neurologic toxicity during treatment. At the first sign of neurologic toxicity, including ICANS, immediately evaluate patient and provide supportive therapy based on severity. Withhold or permanently discontinue TECVAYLI ® based on severity per recommendations and consider further management per current practice guidelines. Due to the potential for neurologic toxicity, patients are at risk of depressed level of consciousness. Advise patients to refrain from driving or operating heavy or potentially dangerous machinery during and for 48 hours after completion of TECVAYLI ® step-up dosing schedule and in the event of new onset of any neurologic toxicity symptoms until neurologic toxicity resolves. TECVAYLI ® is available only through a restricted program under a REMS. TECVAYLI ® and TALVEY ® REMS - TECVAYLI ® is available only through a restricted program under a REMS called the TECVAYLI ® and TALVEY ® REMS because of the risks of CRS and neurologic toxicity, including ICANS. Hepatotoxicity - TECVAYLI ® can cause hepatotoxicity, including fatalities. In patients who received TECVAYLI ® at the recommended dose in the clinical trial, there was one fatal case of hepatic failure. Elevated aspartate aminotransferase (AST) occurred in 34% of patients, with Grade 3 or 4 elevations in 1.2%. Elevated alanine aminotransferase (ALT) occurred in 28% of patients, with Grade 3 or 4 elevations in 1.8%. Elevated total bilirubin occurred in 6% of patients with Grade 3 or 4 elevations in 0.6%. Liver enzyme elevation can occur with or without concurrent CRS. Monitor liver enzymes and bilirubin at baseline and during treatment as clinically indicated. Withhold TECVAYLI ® or consider permanent discontinuation of TECVAYLI ® based on severity. Infections - TECVAYLI ® can cause severe, life-threatening, or fatal infections. In patients who received TECVAYLI ® at the recommended dose in the clinical trial, serious infections, including opportunistic infections, occurred in 30% of patients, with Grade 3 or 4 infections in 35%, and fatal infections in 4.2%. Monitor patients for signs and symptoms of infection prior to and during treatment with TECVAYLI ® and treat appropriately. Administer prophylactic antimicrobials according to guidelines. Withhold TECVAYLI ® or consider permanent discontinuation of TECVAYLI ® based on severity. Monitor immunoglobulin levels during treatment with TECVAYLI ® and treat according to guidelines, including infection precautions and antibiotic or antiviral prophylaxis. Neutropenia - TECVAYLI ® can cause neutropenia and febrile neutropenia. In patients who received TECVAYLI ® at the recommended dose in the clinical trial, decreased neutrophils occurred in 84% of patients, with Grade 3 or 4 decreased neutrophils in 56%. Febrile neutropenia occurred in 3% of patients. Monitor complete blood cell counts at baseline and periodically during treatment and provide supportive care per local institutional guidelines. Monitor patients with neutropenia for signs of infection. Withhold TECVAYLI ® based on severity. Hypersensitivity and Other Administration Reactions - TECVAYLI ® can cause both systemic administration-related and local injection-site reactions. Systemic Reactions - In patients who received TECVAYLI ® at the recommended dose in the clinical trial, 1.2% of patients experienced systemic-administration reactions, which included Grade 1 recurrent pyrexia and Grade 1 swollen tongue. Local Reactions - In patients who received TECVAYLI ® at the recommended dose in the clinical trial, injection-site reactions occurred in 35% of patients, with Grade 1 injection-site reactions in 30% and Grade 2 in 4.8%. Withhold TECVAYLI ® or consider permanent discontinuation of TECVAYLI ® based on severity. Embryo-Fetal Toxicity - Based on its mechanism of action, TECVAYLI ® may cause fetal harm when administered to a pregnant woman. Advise pregnant women of the potential risk to the fetus. Advise females of reproductive potential to use effective contraception during treatment with TECVAYLI ® and for 5 months after the last dose. ADVERSE REACTIONS The most common adverse reactions (≥20%) were pyrexia, CRS, musculoskeletal pain, injection site reaction, fatigue, upper respiratory tract infection, nausea, headache, pneumonia, and diarrhea. The most common Grade 3 to 4 laboratory abnormalities (≥20%) were decreased lymphocytes, decreased neutrophils, decreased white blood cells, decreased hemoglobin, and decreased platelets. Please read full Prescribing Information , including Boxed WARNING, for TECVAYLI ® . DARZALEX FASPRO ® INDICATIONS AND IMPORTANT SAFETY INFORMATION INDICATIONS DARZALEX FASPRO ® (daratumumab and hyaluronidase-fihj) is indicated for the treatment of adult patients with multiple myeloma: IMPORTANT SAFETY INFORMATION CONTRAINDICATIONS DARZALEX FASPRO ® is contraindicated in patients with a history of severe hypersensitivity to daratumumab, hyaluronidase, or any of the components of the formulation. WARNINGS AND PRECAUTIONS Hypersensitivity and Other Administration Reactions Both systemic administration-related reactions, including severe or life-threatening reactions, and local injection-site reactions can occur with DARZALEX FASPRO ® . Fatal reactions have been reported with daratumumab-containing products, including DARZALEX FASPRO ® . Systemic Reactions In a pooled safety population of 1249 patients with multiple myeloma (N=1056) or light chain (AL) amyloidosis (N=193) who received DARZALEX FASPRO ® as monotherapy or in combination, 7% of patients experienced a systemic administration-related reaction (Grade 2: 3.2%, Grade 3: 0.7%, Grade 4: 0.1%). Systemic administration-related reactions occurred in 7% of patients with the first injection, 0.2% with the second injection, and cumulatively 1% with subsequent injections. The median time to onset was 2.9 hours (range: 5 minutes to 3.5 days). Of the 165 systemic administration-related reactions that occurred in 93 patients, 144 (87%) occurred on the day of DARZALEX FASPRO ® administration. Delayed systemic administration-related reactions have occurred in 1% of the patients. Severe reactions included hypoxia, dyspnea, hypertension, tachycardia, and ocular adverse reactions, including choroidal effusion, acute myopia, and acute angle closure glaucoma. Other signs and symptoms of systemic administration-related reactions may include respiratory symptoms, such as bronchospasm, nasal congestion, cough, throat irritation, allergic rhinitis, and wheezing, as well as anaphylactic reaction, pyrexia, chest pain, pruritus, chills, vomiting, nausea, hypotension, and blurred vision. Pre-medicate patients with histamine-1 receptor antagonist, acetaminophen, and corticosteroids. Monitor patients for systemic administration-related reactions, especially following the first and second injections. For anaphylactic reaction or life-threatening (Grade 4) administration-related reactions, immediately and permanently discontinue DARZALEX FASPRO ® . Consider administering corticosteroids and other medications after the administration of DARZALEX FASPRO ® depending on dosing regimen and medical history to minimize the risk of delayed (defined as occurring the day after administration) systemic administration-related reactions. Ocular adverse reactions, including acute myopia and narrowing of the anterior chamber angle due to ciliochoroidal effusions with potential for increased intraocular pressure or glaucoma, have occurred with daratumumab-containing products. If ocular symptoms occur, interrupt DARZALEX FASPRO ® and seek immediate ophthalmologic evaluation prior to restarting DARZALEX FASPRO ® . Local Reactions In this pooled safety population, injection-site reactions occurred in 7% of patients, including Grade 2 reactions in 0.8%. The most frequent (>1%) injection-site reaction was injection-site erythema. These local reactions occurred a median of 5 minutes (range: 0 minutes to 6.5 days) after starting administration of DARZALEX FASPRO ® . Monitor for local reactions and consider symptomatic management. Neutropenia Daratumumab may increase neutropenia induced by background therapy. Monitor complete blood cell counts periodically during treatment according to manufacturer's prescribing information for background therapies. Monitor patients with neutropenia for signs of infection. Consider withholding DARZALEX FASPRO ® until recovery of neutrophils. In lower body weight patients receiving DARZALEX FASPRO ® , higher rates of Grade 3-4 neutropenia were observed. Thrombocytopenia Daratumumab may increase thrombocytopenia induced by background therapy. Monitor complete blood cell counts periodically during treatment according to manufacturer's prescribing information for background therapies. Consider withholding DARZALEX FASPRO ® until recovery of platelets. Embryo-Fetal Toxicity Based on the mechanism of action, DARZALEX FASPRO ® can cause fetal harm when administered to a pregnant woman. DARZALEX FASPRO ® may cause depletion of fetal immune cells and decreased bone density. Advise pregnant women of the potential risk to a fetus. Advise females with reproductive potential to use effective contraception during treatment with DARZALEX FASPRO ® and for 3 months after the last dose. The combination of DARZALEX FASPRO ® with lenalidomide, thalidomide, or pomalidomide is contraindicated in pregnant women because lenalidomide, thalidomide, and pomalidomide may cause birth defects and death of the unborn child. Refer to the lenalidomide, thalidomide, or pomalidomide prescribing information on use during pregnancy. Interference With Serological Testing Daratumumab binds to CD38 on red blood cells (RBCs) and results in a positive indirect antiglobulin test (indirect Coombs test). Daratumumab-mediated positive indirect antiglobulin test may persist for up to 6 months after the last daratumumab administration. Daratumumab bound to RBCs masks detection of antibodies to minor antigens in the patient's serum. The determination of a patient's ABO and Rh blood type are not impacted. Notify blood transfusion centers of this interference with serological testing and inform blood banks that a patient has received DARZALEX FASPRO ® . Type and screen patients prior to starting DARZALEX FASPRO ® . Interference With Determination of Complete Response Daratumumab is a human immunoglobulin G (IgG) kappa monoclonal antibody that can be detected on both the serum protein electrophoresis (SPE) and immunofixation (IFE) assays used for the clinical monitoring of endogenous M-protein. This interference can impact the determination of complete response and of disease progression in some DARZALEX FASPRO ® -treated patients with IgG kappa myeloma protein. ADVERSE REACTIONS In multiple myeloma, the most common adverse reaction (≥20%) with DARZALEX FASPRO ® monotherapy is upper respiratory tract infection. The most common adverse reactions with combination therapy (≥20% for any combination) include fatigue, nausea, diarrhea, dyspnea, insomnia, headache, pyrexia, cough, muscle spasms, back pain, vomiting, hypertension, upper respiratory tract infection, peripheral sensory neuropathy, constipation, pneumonia, and peripheral edema. The most common hematology laboratory abnormalities (≥40%) with DARZALEX FASPRO ® are decreased leukocytes, decreased lymphocytes, decreased neutrophils, decreased platelets, and decreased hemoglobin. Please click here to see the full Prescribing Information for DARZALEX FASPRO ® . About Johnson & Johnson At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com/ or at www.innovativemedicine.jnj.com . Follow us at @JanssenUS and @JNJInnovMed . Janssen Research & Development, LLC and Janssen Biotech, Inc. are both Johnson & Johnson companies. Cautions Concerning Forward-Looking Statements This press release contains "forward-looking statements" as defined in the Private Securities Litigation Reform Act of 1995 regarding product development and the potential benefits and treatment impact of TECVAYLI ® (teclistamab-cqyv ) and DARZALEX FASPRO ® (daratumumab and hyaluronidase-fihj). The reader is cautioned not to rely on these forward-looking statements. These statements are based on current expectations of future events. If underlying assumptions prove inaccurate or known or unknown risks or uncertainties materialize, actual results could vary materially from the expectations and projections of Janssen Research & Development, LLC, Janssen Biotech, Inc., and/or Johnson & Johnson. Risks and uncertainties include, but are not limited to: challenges and uncertainties inherent in product research and development, including the uncertainty of clinical success and of obtaining regulatory approvals; uncertainty of commercial success; manufacturing difficulties and delays; competition, including technological advances, new products and patents attained by competitors; challenges to patents; product efficacy or safety concerns resulting in product recalls or regulatory action; changes in behavior and spending patterns of purchasers of health care products and services; changes to applicable laws and regulations, including global health care reforms; and trends toward health care cost containment. A further list and descriptions of these risks, uncertainties and other factors can be found in Johnson & Johnson's Annual Report on Form 10-K for the fiscal year ended December 31, 2023 , including in the sections captioned "Cautionary Note Regarding Forward-Looking Statements" and "Item 1A. Risk Factors," and in Johnson & Johnson's subsequent Quarterly Reports on Form 10-Q and other filings with the Securities and Exchange Commission. Copies of these filings are available online at www.sec.gov , www.jnj.com or on request from Johnson & Johnson. None of Janssen Research & Development, LLC, Janssen Biotech, Inc. nor Johnson & Johnson undertake to update any forward-looking statement as a result of new information or future events or developments. * Marc S. Raab , M.D., has provided consulting, advisory, and speaking services to Johnson & Johnson; he has not been paid for any media work. 1 Raab, Marc, S., et al, 493 Phase 2 Study of Teclistamab-Based Induction Regimens in Patients with Transplant-Eligible (TE) Newly Diagnosed Multiple Myeloma (NDMM): Results from the GMMG-HD10/DSMM-XX (MajesTEC-5) Trial. 2024 American Society of Hematology Annual Meeting. December 2024 . 2 Zamagni, Elena, et al., 494 Phase 3 Study of Teclistamab (Tec) in Combination with Lenalidomide (Len) and Tec Alone Versus Len Alone in Newly Diagnosed Multiple Myeloma (NDMM) As Maintenance Therapy Following Autologous Stem Cell Transplantation (ASCT): Safety Run-in (SRI) Results from the MajesTEC-4/EMN30 Trial. 2024 American Society of Hematology Annual Meeting. December 2024 . 3 GMMG-HD10 / DSMM-XX / 64007957MMY2003, MajesTEC-5 (HD10/DSMMXX). https://clinicaltrials.gov/study/NCT05695508 . Accessed November 2024 . 4 Phase 3 Study of Teclistamab in Combination With Lenalidomide and Teclistamab Alone Versus Lenalidomide Alone in Participants With Newly Diagnosed Multiple Myeloma as Maintenance Therapy Following Autologous Stem Cell Transplantation (MajesTEC-4). https://clinicaltrials.gov/study/NCT05243797 . Accessed November 2024 . 5 A Study of Teclistamab in Combination With Daratumumab and Lenalidomide (Tec-DR) and Talquetamab in Combination With Daratumumab and Lenalidomide (Tal-DR) in Participants With Newly Diagnosed Multiple Myeloma (MajesTEC-7). https://classic.clinicaltrials.gov/ct2/show/NCT05552222 . Accessed November 2024 . 6 U.S. FDA Approves TECVAYLI ® (teclistamab-cqyv), the First Bispecific T-cell Engager Antibody for the Treatment of Patients with Relapsed or Refractory Multiple Myeloma. https://www.jnj.com/u-s-fda-approves-tecvayli-teclistamab-cqyv-the-first-bispecific-t-cell-engager-antibody-for-the-treatment-of-patients-with-relapsed-or-refractory-multiple-myeloma . Accessed November 2024 . 7 Rajkumar SV. Multiple myeloma: 2020 update on diagnosis, risk-stratification and management. Am J Hematol. 2020;95(5):548-5672020;95(5):548-567. http://www.ncbi.nlm.nih.gov/pubmed/32212178 8 National Cancer Institute. Plasma Cell Neoplasms. https://www.cancer.gov/types/myeloma/patient/myeloma-treatment-pdq . Accessed November 2024 . 9 City of Hope. Multiple Myeloma: Causes, Symptoms & Treatments. https://www.cancercenter.com/cancer-types/multiple-myeloma . Accessed November 2024 . 10 American Cancer Society. Key Statistics About Multiple Myeloma. https://www.cancer.org/cancer/multiple-myeloma/about/key-statistics.html#:~:text=Multiple%20myeloma%20is%20a%20relatively,men%20and%2015%2C370%20in%20women . Accessed November 2024 . 11 SEER Explorer: An interactive website for SEER cancer statistics [Internet]. Surveillance Research Program, National Cancer Institute. https://seer.cancer.gov/explorer/ . Accessed November 2024 . 12 American Cancer Society. What is Multiple Myeloma? https://www.cancer.org/cancer/multiple-myeloma/about/what-is-multiple-myeloma.html . Accessed November 2024 . 13 American Cancer Society. Multiple Myeloma Early Detection, Diagnosis, and Staging. https://www.cancer.org/cancer/types/multiple-myeloma/detection-diagnosis-staging/detection.html . Accessed November 2024 . Media contacts: Sarah Freeman sfreem21@its.jnj.com Christie Corbett ccorbet6@its.jnj.com Investor contact: Lauren Johnson investor-relations@its.jnj.com U.S. Medical Inquiries +1 800 526-7736 View original content to download multimedia: https://www.prnewswire.com/news-releases/tecvayli-teclistamab-cqyv-demonstrates-potential-as-frontline-combination-therapy-for-patients-with-newly-diagnosed-multiple-myeloma-302325575.html SOURCE Johnson & JohnsonFacebook Twitter WhatsApp SMS Email Print Copy article link Save Players must be assigned female at birth or have transitioned to female before going through male puberty to compete in LPGA tournaments or the eight USGA championships for females under new gender policies published Wednesday. The policies, which begin in 2025, follow more than a year of study involving medicine, science, sport physiology and gender policy law. The updated policies would rule out eligibility for Hailey Davidson, who missed qualifying for the U.S. Women’s Open this year by one shot and came up short in LPGA Q-school. Davidson, who turned 32 on Tuesday, began hormone treatments when she was in her early 20s in 2015 and in 2021 underwent gender-affirming surgery, which was required under the LPGA’s previous gender policy. She had won this year on a Florida mini-tour called NXXT Golf until the circuit announced in March that players had to be assigned female at birth. Hammonton police sergeant accused of failing drug test, stealing drugs from evidence room Mays Landing man charged in hit-and-run that injured man, killed dog in Absecon $680,000 Atlantic City charter bus purchase mostly covered by state, Small says Pleasantville man accused of murdering girlfriend Mainland Regional falls to Old Tappan in state final 4 Bridgeton men indicted in alleged sex trafficking ring Everything you need to know about Mainland Regional's state title game Wonderland developer to pitch vision again Wednesday at Ocean City Tabernacle Atlantic City mayor waives first appearance on witness tampering charge Northfield Councilman Leeds resigns, citing concerns over Mayor Chau's criminal charges Some Atlantic City casino workers call on union boss to resign for opposing a smoking ban Mays Landing man busted for meth Northfield intersection to become four-way stop Biden pardons his son Hunter despite previous pledges not to Longport administrator and former police chief Scott Porter dies “Can’t say I didn’t see this coming,” Davidson wrote Wednesday on an Instagram story. “Banned from the Epson and the LPGA. All the silence and people wanting to stay ‘neutral’ thanks for absolutely nothing. This happened because of all your silence.” LPGA commissioner Mollie Marcoux Samaan, who is resigning in January, said the new gender policy “is reflective of an extensive, science-based and inclusive approach.” By making it to the second stage of Q-school, Davidson would have had very limited status on the Epson Tour, the pathway to the LPGA. The LPGA and USGA say their policies were geared toward being inclusive of gender identities and expression while striving for equity in competition. The LPGA said its working group of experts advised that the effects of male puberty allowed for competitive advantages in golf compared with players who had not gone through puberty. “Our policy is reflective of an extensive, science-based and inclusive approach,” said LPGA Commissioner Mollie Marcoux Samaan, who announced Monday that she is resigning in January. “The policy represents our continued commitment to ensuring that all feel welcome within our organization, while preserving the fairness and competitive equity of our elite competitions.” Mike Whan, the former LPGA commissioner and now CEO of the USGA, said it developed the updated policy independently and later discovered it was similar to those used by swimming, track and field, and other sports. United States Golf Association CEO Mike Whan said the new policy will prevent anyone from having “a competitive advantage based on their gender.” “It starts with competitive fairness as the North star,” Whan said in a telephone interview. “We tried not to get into politics, or state by state or any of that stuff. We just simply said, ‘Where would somebody — at least medically today — where do we believe somebody would have a competitive advantage in the field?’ And we needed to draw a line. “We needed to be able to walk into any women’s event and say with confidence that nobody here has a competitive advantage based on their gender. And this policy delivers that.” The “Competitive Fairness Gender Policy” for the USGA takes effect for the 2025 championship season that starts with the U.S. Women’s Amateur Four-Ball on May 10-14. Qualifying began late this year, though there were no transgender players who took part. “Will that change in the years to come as medicine changes? Probably,” Whan said. “But I think today this stacks up.” The LPGA “Gender Policy for Competition Eligibility” would apply to the LPGA Tour, Epson Tour, Ladies European Tour and qualifying for the tours. Players assigned male at birth must prove they have not experienced any part of puberty beyond the first stage or after age 12, whichever comes first, and then meet limitation standards for testosterone levels. The LPGA begins its 75th season on Jan. 30 with the Tournament of Champions in Orlando, Florida. Buffalo Bills quarterback Josh Allen, foreground right, dives toward the end zone to score past San Francisco 49ers defensive end Robert Beal Jr. (51) and linebacker Dee Winters during the second half of an NFL football game in Orchard Park, N.Y., Sunday, Dec. 1, 2024. (AP Photo/Adrian Kraus) South Carolina guard Maddy McDaniel (1) drives to the basket against UCLA forward Janiah Barker (0) and center Lauren Betts (51) during the first half of an NCAA college basketball game, Sunday, Nov. 24, 2024, in Los Angeles. (AP Photo/Eric Thayer) Mari Fukada of Japan falls as she competes in the women's Snowboard Big Air qualifying round during the FIS Snowboard & Freeski World Cup 2024 at the Shougang Park in Beijing, Saturday, Nov. 30, 2024. (AP Photo/Andy Wong) LSU punter Peyton Todd (38) kneels in prayer before an NCAA college football game against Oklahoma in Baton Rouge, La., Saturday, Nov. 30, 2024. LSU won 37-17. (AP Photo/Gerald Herbert) South Africa's captain Temba Bavuma misses a catch during the fourth day of the first Test cricket match between South Africa and Sri Lanka, at Kingsmead stadium in Durban, South Africa, Saturday, Nov. 30, 2024. (AP Photo/Themba Hadebe) Philadelphia Eagles running back Saquon Barkley, left, is hit by Baltimore Ravens cornerback Marlon Humphrey, center, as Eagles wide receiver Parris Campbell (80) looks on during a touchdown run by Barkley in the second half of an NFL football game, Sunday, Dec. 1, 2024, in Baltimore. (AP Photo/Stephanie Scarbrough) Los Angeles Kings left wing Warren Foegele, left, trips San Jose Sharks center Macklin Celebrini, center, during the third period of an NHL hockey game Monday, Nov. 25, 2024, in San Jose, Calif. (AP Photo/Godofredo A. Vásquez) Olympiacos' Francisco Ortega, right, challenges for the ball with FCSB's David Miculescu during the Europa League league phase soccer match between FCSB and Olympiacos at the National Arena stadium, in Bucharest, Romania, Thursday, Nov. 28, 2024. (AP Photo/Andreea Alexandru) Brazil's Botafogo soccer fans react during the Copa Libertadores title match against Atletico Mineiro in Argentina, during a watch party at Nilton Santos Stadium, in Rio de Janeiro, Saturday, Nov. 30, 2024. (AP Photo/Bruna Prado) Seattle Kraken fans react after a goal by center Matty Beniers against the San Jose Sharks was disallowed due to goaltender interference during the third period of an NHL hockey game Saturday, Nov. 30, 2024, in Seattle. The Sharks won 4-2. (AP Photo/Lindsey Wasson) New York Islanders left wing Anders Lee (27), center, fight for the puck with Boston Bruins defensemen Parker Wotherspoon (29), left, and Brandon Carlo (25), right during the second period of an NHL hockey game, Wednesday, Nov. 27, 2024, in Elmont, N.Y. (AP Photo/Julia Demaree Nikhinson) Jiyai Shin of Korea watches her shot on the 10th hole during the final round of the Australian Open golf championship at the Kingston Heath Golf Club in Melbourne, Australia, Sunday, Dec. 1, 2024. (AP Photo/Asanka Brendon Ratnayake) Mathilde Gremaud of Switzerland competes in the women's Freeski Big Air qualifying round during the FIS Snowboard & Freeski World Cup 2024 at the Shougang Park in Beijing, Friday, Nov. 29, 2024. (AP Photo/Andy Wong) Lara Gut-Behrami, of Switzerland, competes during a women's World Cup giant slalom skiing race, Saturday, Nov. 30, 2024, in Killington, Vt. (AP Photo/Robert F. Bukaty) New York Islanders goaltender Ilya Sorokin cools off during first period of an NHL hockey game against the Boston Bruins, Wednesday, Nov. 27, 2024, in Elmont, N.Y. (AP Photo/Julia Demaree Nikhinson) Brazil's Amanda Gutierres, second right, is congratulated by teammate Yasmin, right, after scoring her team's first goal during a soccer international between Brazil and Australia in Brisbane, Australia, Thursday, Nov. 28, 2024. (AP Photo/Pat Hoelscher) Las Vegas Raiders tight end Brock Bowers (89) tries to leap over Kansas City Chiefs cornerback Joshua Williams (2) during the first half of an NFL football game in Kansas City, Mo., Friday, Nov. 29, 2024. (AP Photo/Ed Zurga) Luiz Henrique of Brazil's Botafogo, right. is fouled by goalkeeper Everson of Brazil's Atletico Mineiro inside the penalty area during a Copa Libertadores final soccer match at Monumental stadium in Buenos Aires, Argentina, Saturday, Nov. 30, 2024. (AP Photo/Natacha Pisarenko) Gold medalists Team Netherlands competes in the Team Sprint Women race of the ISU World Cup Speed Skating Beijing 2024 held at the National Speed Skating Oval in Beijing, Sunday, Dec. 1, 2024. (AP Photo/Ng Han Guan) Minnesota Vikings running back Aaron Jones (33) reaches for an incomplete pass ahead of Arizona Cardinals linebacker Mack Wilson Sr. (2) during the second half of an NFL football game Sunday, Dec. 1, 2024, in Minneapolis. (AP Photo/Abbie Parr) Melanie Meillard, center, of Switzerland, competes during the second run in a women's World Cup slalom skiing race, Sunday, Dec. 1, 2024, in Killington, Vt. (AP Photo/Robert F. Bukaty) Houston Rockets guard Jalen Green goes up for a dunk during the second half of an Emirates NBA cup basketball game against the Minnesota Timberwolves, Tuesday, Nov. 26, 2024, in Minneapolis. (AP Photo/Abbie Parr) England's Alessia Russo, left, and United States' Naomi Girma challenge for the ball during the International friendly women soccer match between England and United States at Wembley stadium in London, Saturday, Nov. 30, 2024. (AP Photo/Kirsty Wigglesworth) Get in the game with our Prep Sports Newsletter Sent weekly directly to your inbox!

Have you been drinking more than usual? A new blood test could soon reveal whether your alcohol consumption is harming your liver. Researchers report that a blood-borne byproduct of alcohol called phosphatidyl ethanol (PEth) offers a reliable way to assess liver scarring caused by excessive drinking. This innovative method, published in the American Journal of Gastroenterology, has the potential to revolutionize how doctors diagnose and monitor alcohol-related liver damage. PEth testing provides a more accurate picture of alcohol-related harm compared to relying on self-reported drinking habits. According to Judy Hahn, senior researcher and professor at the University of California, San Francisco (UCSF), this approach is akin to how other health risks are measured: “We don’t ask someone how much fatty food they eat; we measure their cholesterol. Similarly, we weigh people rather than asking how much they think they weigh,” Hahn explained in a UCSF news release. How the Test Works? When the body processes alcohol, it produces PEth, a compound that correlates directly with alcohol consumption. Previous studies have confirmed that blood concentrations of PEth accurately reflect the quantity of alcohol consumed, making it a promising biomarker for liver damage. This test could enable healthcare professionals to better understand a patient's drinking patterns and offer tailored advice to prevent long-term complications. The Scope of the Study Researchers pooled data from 12 studies conducted across the United States, Russia, Uganda, and South Africa, analyzing over 4,600 participants. These studies included PEth testing, self-reported alcohol use, and liver damage measurements. The findings revealed that elevated PEth levels strongly correlated with liver damage scores. In contrast, self-reports of drinking habits showed weaker associations with liver scarring, likely due to underreporting or memory lapses among participants. “This is the largest study yet to examine the relationship between PEth and liver damage,” researchers noted. It’s also the first to compare the effectiveness of PEth testing against self-reports in assessing the risk of liver scarring. The results underline the importance of integrating PEth tests into routine blood work. Why It Matters Heavy drinking is a widespread issue in the United States, with about 24 per cent of adults binge drinking and over 6 per cent classified as heavy drinkers, according to the U.S. Centers for Disease Control and Prevention. Alcohol-related liver disease is a growing public health concern, especially as drinking levels surged during the COVID-19 pandemic. Liver scarring, also known as fibrosis, can be slowed or even reversed by reducing alcohol intake and adopting a healthy diet low in sugar, salt, and fat. However, early detection is crucial to prevent the condition from progressing to more severe stages like cirrhosis or liver failure. The study's lead researcher, Pamela Murnane, an assistant professor of epidemiology and biostatistics at UCSF, emphasized the need for routine PEth testing: “To prevent and manage liver fibrosis, we need to know how much a person is drinking. Self-reports simply don’t provide an accurate grasp of that.” Incorporating PEth testing into standard blood panels could help identify at-risk individuals earlier, allowing for timely interventions to protect liver health. As researchers continue to explore this technology, it holds promise for improving how alcohol-related liver disease is diagnosed and treated, ultimately saving lives. Get Latest News Live on Times Now along with Breaking News and Top Headlines from Health and around the world.

Meta is preparing for a groundbreaking infrastructure project: a 40,000+ kilometer subsea fiber-optic cable encircling the globe. The initiative, expected to cost over $10 billion, marks the first time Meta will own and operate a subsea cable exclusively. Sources close to TechCrunch confirmed the plans, which aim to secure seamless data flow for its platforms like Facebook, Instagram, and WhatsApp. A strategic step for Meta According to the report, the plan begins with a $2 billion budget, but as it scales, the cost could exceed $10 billion. The cable will follow a “W” route, connecting the US east coast to India via South Africa and returning to the US west coast via Australia. The route "avoids areas of geopolitical tension,” a source close to Meta revealed, the report said, referring to recent incidents where subsea cables were damaged by conflict, such as in the Red Sea and the Baltic Sea. India: A key landing point The technology media company highlighted India’s pivotal role in the project. “India could become the training capital of the world,” the source was quoted as saying, citing Meta’s potential plans to build AI training facilities and data centers in the country. India is Meta ’s largest market, with more than 375 million Facebook users, 363 million Instagram users, and 536 million WhatsApp users. The country’s enthusiasm for emerging features like AI tools, combined with a growing data center market, underscores its importance in Meta’s strategy. Broader implications The project reflects a shift in the tech industry, with companies like Meta and Google increasingly investing in private subsea cables to control their data infrastructure. "Tech companies want direct ownership of the pipes needed to deliver content, advertising and more to users around the world," the source said as per the report. Beyond business advantages, geopolitical considerations are also driving the move, the report noted, saying recent attacks and damages to submarine cables have highlighted vulnerabilities in traditional routes, and Meta ’s cable seeks to mitigate these risks while ensuring uninterrupted service to its platforms. Future outlook Although the project is in its early stages, as per the sources cited in the report, Meta will announce details in early 2025. However, challenges loom, including limited availability of manufacturers which are already engaged with other major clients. " AI is part of Meta’s long-term infrastructure roadmap, .... it’s too soon to say whether AI is part of the equation for Meta in this project, describing it as part of the “long tail” of considerations and possibilities," the source was quoted as saying. Meta declined to comment on the project, the report added. However, as the tech giant aims to expand its global reach and cement its infrastructure dominance, this subsea cable could become a cornerstone of its future operations.Don't ignore birth rate dip

By William Lambers The poem, “ ‘ Twas the Night Before Christmas” reads, “The stockings were hung by the chimney with care, In hopes that St. Nicholas soon would be there.” It was the real life St. Nicholas, a 4th century bishop known for his secret gift giving, who inspired the poem and the creation of the “Santa Claus” we know today. But if we want to be true to the real Santa, St. Nicholas, we should give food to the world’s starving people this holiday. For St. Nicholas was known for his work in feeding the hungry. It was St. Nicholas who provided food to the poor during times of famine. Legend has it that St. Nicholas was able to convince others to share food to help those in hunger. The lesson was there is enough food and wealth in the world to feed everyone. Sharing is the true Christmas spirit. With food banks seeing high demand at home and unprecedented hunger emergencies worldwide, the best Christmas gift we could give is food to those in desperate need. The starving child in a refugee camp in the D. R. Congo wants a basket of food more than anything right now. Families in war-torn Gaza, Sudan, Yemen and Syria are desperate for food amid horrible conflicts. But yet there is not enough funding to reach all those suffering in hunger. For the coming year the UN World Food Program (WFP) is appealing for “$16.9 billion to address global food needs and the alarming gap between needs and resources.” That figure is what the world spends drinking coffee for two weeks according to WFP. There are mothers in Sudan, Madagascar, D.R. Congo, and other countries who want a box of Plumpy’Nut this holiday because this enriched food will save their child’s life. There is a major shortage of life-saving food for infants right now. UNICEF, the UN Children’s agency, recently issued an appeal for $165 million because supplies of Ready-to-use-Therapeutic-Food (RUTF) to treat infant malnutrition are running low in 12 nations. These alarming shortages are a disaster as small children will suffer lasting physical and mental damage from malnutrition, or death. Mali, Nigeria, Niger, Chad, Cameroon, Pakistan, Sudan, Madagascar, South Sudan, Kenya, the Democratic Republic of Congo and Uganda are all at risk of running out of food to treat infant malnutrition. The charity Mary’s Meals gives school lunches to children in some of the most impoverished countries in the world. These school lunches are a precious gift to children, giving them life and hope for the future. “Through our collaborative school feeding programs in 17 countries, we see first-hand the hope these initiatives bring to families and communities. Even in the direst circumstances, when children are nourished and able to attend school, these programs provide a sense of stability and hope that with an education, there’s an opportunity for a better future,” said Mary’s Meals USA Executive Director Terry Bonet. What an amazing Christmas it would be if everyone who is facing starvation got life-saving food. That would be what St. Nicholas would do, giving gifts of food to the hungry. You can send a donation to charities like WFP, UNICEF, Mary’s Meals, Save the Children, Catholic Relief Services, Mercy Corps, CARE, Edesia and many others. You could even make the donation in someone’s name to honor them this holiday season. You could leave them a card so they know that the gift of food is on the way to the starving children. That would be in the spirit of St. Nicholas, a Happy Christmas with Food for all, and to all peace and a good night. William Lambers is an author who partnered with the UN World Food Program on the book Ending World Hunger.Cardi B's staggering monthly spending habits revealed after rapper is accused of going broke Cardi, 32, was trolled after taking an endorsement deal with Shein She responded by sharing receipts to prove just how wealthy she is READ MORE: Cardi B reveals her natural hair By J. PETERSON FOR DAILYMAIL.COM Published: 17:48 EST, 4 December 2024 | Updated: 17:59 EST, 4 December 2024 e-mail 55 shares 12 View comments Cardi B has exposed her own lavish spending habits after fans questioned her finances. The rapper, 32, was trolled after she partnered with affordable fast fashion brand Shein for a sponsored social media deal, leading some fans to wonder if she was still making a sizable income from her music career. 'Girl, you wear Hermes and Chanel , not Shein,' commented one, while another wrote, 'This is so embarrassing, Shein promo.' Furious at the speculation, Cardi took to social media to rant about her bank balance. Not only did she brag about spending '$3 million a month,' she also posted a text message exchange that showed that she'd turned down $65 million to go on tour. 'People are saying I'm surviving off Shein deals and brand deals,' she said on X Spaces. Cardi B has exposed her own lavish spending habits after fans questioned her finances 'I want to let y'all know I could wake up tomorrow, sign a contract, and have half of $65 million - or half of $70 million - in my account.' According to the details of the tour deal, the rapper could earn $1.1 million per tour date, $1.5 million for festival shows, and $65 million to go on tour. However, she turned down the offer in the hope that she could earn even more if she waited to time the tour with her long-awaited sophomore album, which is due out next year. 'I'm not taking tour deals until I announce my album because once I do, I know those offers will go up. You have to move smart. You can't act hungry when you're not,' she said. Cardi also posted receipts to show off some of her most expensive purchases, which included dropping $200,000 on bling from bespoke jeweler Eliantte & Co. She spent another $120,000 on Benny the Jeweler, who is known for working with famous rappers, and then $65,000 from luxury resale website Adore the Couture. Cardi's status in the music industry has come into question recently due to the constant delay of her sophomore album . The disc has repeatedly been delayed since 2022, and is now currently due out in 2025. Not only did she brag about spending '$3 million a month', she also posted a text message exchange that showed that she'd turned down $65 million to go on tour Cardi also shared receipts to show that she was spending six figures at various jewelers Her last solo single 'Enough (Miami)' reached the top 10 on the Hot 100 but quickly plunged down the charts. In 2023, she attempted to recreate the success of her smash hit 'WAP' by reteaming with Megan Thee Stallion for the collaboration Bongos , but the song missed the top 10. Cardi's last hit single as a solo artist was 'Up,' which hit No. 1 on the Hot 100 in 2021. Despite slipping on the charts, Cardi is still a hot commodity when it comes to lucrative endorsement deals. The Bronx-born beauty has worked with McDonald's, Marc Jacobs, and Nyx Cosmetics over the last 18 months. She also has her own line of alcohol-infused whipped cream called Whipshots. In a post to X back in April, Cardi bragged that she earns up to $5 million per deal these days. 'Right now I get brand deals for over $5 million for a campaign... I got social media famous in 2014... my first brand deal from Fashion Nova was in 2016 and $200 a post,' she posted. 'You could reach any height no matter how ghetto or where you come from.' Chanel Cardi B Share or comment on this article: Cardi B's staggering monthly spending habits revealed after rapper is accused of going broke e-mail 55 shares Add comment

Americans stocking up for this year’s Thanksgiving dinner should see a dip in their grocery bills for the second year in a row, according to the 39th annual American Farm Bureau Federation survey of the ingredients for a classic feast. A dinner for 10 is estimated to cost $58.90 in the Midwest, down 5% from last year. However, this is still 19% higher than pre-pandemic years. While consumers are getting some relief after years of elevated retail prices, these grocery bills also reflect some hard conversations around the dinner table for farm and ranch families. “We should all be thankful that we live in a country with such an abundant food supply,” Zippy Duval, the American Farm Bureau president, said in a statement Wednesday. “We are seeing modest improvements in the cost of a Thanksgiving dinner for a second year, but America’s families, including farm families, are still being hurt by high inflation.” For one week each year, volunteer shoppers from all 50 states and Puerto Rico visit their local grocery store or its website to survey the prices of items for the feast. Since 1986, the volunteers have collected price data on turkey, cubed stuffing, sweet potatoes, dinner rolls, frozen peas, fresh cranberries, celery, carrots, pumpkin pie mix and crusts, whipping cream and whole milk. Thanksgiving meals in 2024 will cost different amounts, depending on where they are being prepared. The bill for a classic dinner is a mixed bag of savings and squeezes. Seven items dropped in price this year, including turkey, sweet potatoes, frozen peas, a vegetable tray of carrots and celery, pumpkin pie mix, pie crusts and whole milk. However, the remaining four items — dinner rolls, fresh cranberries, whipping cream and cubed stuffing — rose in price. Over the span of the survey, turkey has accounted for an average of 43% of the total dinner cost. This year is right on the mark, the farm bureau said a 16-pound turkey accounts for 44.2% of the cost of a 10-person dinner. Given its large share of the total dinner bill, differences in the grocery bill year-over-year closely follow the change in turkey prices. “The turkey is traditionally the main attraction on the Thanksgiving table and is typically the most expensive part of the meal,” said Bernt Nelson, an economist with the farm bureau. “The American turkey flock is the smallest it’s been since 1985 because of avian influenza, but overall demand has also fallen, resulting in lower prices at the grocery store for families planning a holiday meal.” According to the U.S. Department of Agriculture’s Turkeys Raised report, farmers raised 205 million turkeys in 2024, down 6% from last year and the lowest since 1985. The highly communicable avian influenza is responsible for the decline. Typically, fewer turkeys would mean an increase in price, but demand for turkey fell in 2024. USDA estimates per capita demand for turkey is 13.9 pounds per person, down a pound from 2023. This drop in demand has caused prices to fall, according to the farm bureau. Prices for ham, Russet potatoes and frozen green beans were added to the survey in 2018 to reflect more Thanksgiving favorites, with all of them showing a year-over-year reduction in price. When including the additional items, the meal cost rose to $77.34, or $7.73 per person, with more leftovers, of course. The largest increases in the Thanksgiving dinner bill this year come from processed products. Dinner rolls and cubed stuffing both increased over 8% from 2023. Nonfood inflation and labor shortages have driven up costs for partners across the food supply chain. Buying the goods for Thanksgiving dinner will be a little bit less expensive in 2024 than it was in recent years. Fresh cranberries had the next-largest price increase at 12%. This is a stabilization of prices after a significant 18% drop in prices from 2022 to 2023. Despite the year-over-year price increase, cranberries are still more affordable than historical averages. In fact, when adjusted for inflation, this is the lowest price for cranberries since 1987. The prices for Thanksgiving staples vary across the U.S. In the West, a grocery bill will be at least 14% steeper than the rest of the country: $67.05 for a party of 10. The other regions of the U.S. are lower by $8 or more. Southern dinners will cost the least at $56.81, followed closely by the Northeast at $57.36 and $58.90 in the Midwest, which includes Nebraska. Even though the price tag for this year’s Thanksgiving meal is down 5%, it’s still up nearly 20% from just five years ago. The average American also has to work fewer hours to buy the same meal than in previous years. Wages continued to grow faster following the COVID-19 pandemic, even as inflation cooled. Because average wages rose 4% from 2023 to 2024, it took 9% less work time for us to pay for this year’s Thanksgiving dinner. kevin.cole@owh.com , 402-444-1272 We're always interested in hearing about news in our community. Let us know what's going on! Subscribe to our Daily Headlines newsletter.What To Expect From Trump 2.05 yuan 。

EDMONTON — Alberta Transportation Minister Devin Dreeshen says as of April 1 the province is ending photo radar ticketing on all numbered provincial highways. The province also plans over the coming months to review "cash cows” – photo radar spots that appear to prioritize money-making over safety -- with the goal of shutting down 70 per cent of the current 2,200 sites. Dreeshen says far too often photo radar penalizes drivers without improving road safety, adding the province doesn’t intend to offer extra cash to make municipalities whole from the lost photo radar revenue. “The whole point of getting rid of these cash cow locations is to make sure that photo radar is used as a traffic safety tool and not as a revenue generator,” Dreeshen told a news conference Monday. Photo radar will continue to be allowed in school zones, playground zones and construction sites, but beyond these areas, local governments will have to submit their case and show evidence of higher collision rates. At intersections equipped with cameras, running a red light could still net a driver a ticket, but speeding on green will not - starting in the spring. Kara Westerlund, president of the Rural Municipalities of Alberta, applauded the move. “Our communities have called for change, and I’m proud to say that this government has listened,” she said at the government news conference. Alberta Municipalities president Tyler Gandam said his organization supports local governments using automated traffic enforcement for safety reasons, since the data shows it reduces deaths, injuries and property damage. "It's improving safety in the communities, no question," Gandam said in an interview, adding the government's decision is about political points because getting tickets is unpopular. "If you don't like photo radar, just stop speeding," he said. Gandam said forcing municipalities to go through another approval process represents more bureaucracy from a government that prides itself on cutting red tape. He said photo radar revenue makes up a small portion of any municipality's budget. For him, the issue is about safety, including that of the police officers who will need to enforce traffic safety. Dreeshen said the province has seen a "mixed bag" of data measuring photo radar's effect on collision numbers. "There's lots of folks that will say photo radar is needed to keep these streets safe, but we've also seen municipalities, when they remove photo radar, that we've actually seen safer streets," he said. "We're not banning speed limits," he said. Opposition NDP critic Lorne Dach told reporters Dreeshen's move doesn't appear to be supported by evidence. "The decision-making here seems to be basically based on the minister's decision about popularity rather than public safety data," said Dach. NDP Leader Naheed Nenshi said the government is adding red tape, and that municipalities, including Calgary, use photo radar funding to pay for policing. "If this government wants municipalities to increase property taxes for their largest budget item, they should just say so," he said. The United Conservative Party government has been placing restrictions on photo radar sites in stages. All photo radar sites were removed from ring roads in Calgary and Edmonton last December. Dreeshen said that's shown good results, in part because drivers aren't taken off guard by having to suddenly slow down and disrupt traffic. In 2019, the UCP increased the province’s share of photo radar revenue to 40 per cent from 27. That fiscal year, the revenue generated was $203 million across the province. By last year, total revenue was down to $145 million, Dreeshen said Monday. "At the end of the day, this is going to be a hit to the province (financially) as well." Among the top five revenue-generating sites listed by the government in 2023, four are in Edmonton and area, each collecting between $2.1 million and almost $6 million per year. This report by The Canadian Press was first published Dec. 2, 2024. Lisa Johnson, The Canadian PressRosen Law Firm Encourages Light & Wonder, Inc. Investors to Inquire About Securities Class Action Investigation - LNW

Fed’s recent rate cuts could improve borrowing options for state, local government projectsFight for disability rights in Assam

Shoppers Who Buy Via Email Spend 138% More Than Those Who Don't. Here Are 9 Email Hacks to Capture Their SalesCourt hears legal arguments in sex assault case of five hockey players LONDON, Ont. — Lawyers in the sexual assault case of five members of Canada's 2018 world junior hockey team began what are expected to be several weeks of legal arguments on Monday, ahead of next year's trial. Canadian Press Nov 25, 2024 1:57 PM Share by Email Share on Facebook Share on X Share on LinkedIn Print Share via Text Message Ottawa Senators' Alex Formenton during an NHL hockey game in Philadelphia, Friday, April 29, 2022; New Jersey Devils defenceman Cal Foote before an NHL hockey game in Newark, N.J., Friday, Oct. 27, 2023; New Jersey Devils' Michael McLeod during an NHL hockey game in Philadelphia, Thursday, Nov. 30, 2023; Calgary Flames centre Dillon Dube during an NHL hockey game in Detroit, Sunday, Oct. 22, 2023 and Philadelphia Flyers goaltender Carter Hart during an NHL hockey game in Uniondale, N.Y., Saturday, April 3, 2021. A London, Ont., judge is set to hear legal arguments today in the sexual assault case of five members of Canada's 2018 world junior hockey team. THE CANADIAN PRESS/AP-Matt Slocum, Noah K. Murray, Matt Slocum, Paul Sancya, Corey Sipkin LONDON, Ont. — Lawyers in the sexual assault case of five members of Canada's 2018 world junior hockey team began what are expected to be several weeks of legal arguments on Monday, ahead of next year's trial. Dillon Dube, Carter Hart, Michael McLeod, Cal Foote and Alex Formenton were charged with sexual assault earlier this year in an incident that allegedly took place in London, Ont., in June 2018. McLeod also faces an additional charge of sexual assault for "being a party to the offence." Dube, McLeod and Formenton attended court in person for the first time in London on Monday, all three dressed in dark suits. Lawyers for the players have said their clients plan to defend themselves against the allegations, and all five are expected to plead not guilty. A jury trial is scheduled to begin on April 22 of next year. Court heard Monday the trial will be heard by Justice Maria Carroccia. Several weeks have been set aside for legal arguments before then, but the issues discussed in those hearings cannot be reported at this time due to a publication ban meant to protect the accused's right to a fair trial. This report by The Canadian Press was first published Nov. 25, 2024. The Canadian Press See a typo/mistake? Have a story/tip? This has been shared 0 times 0 Shares Share by Email Share on Facebook Share on X Share on LinkedIn Print Share via Text Message More National Sports Rock On! Top-flight curling returns to St. John's for first time since 2017 Brier Nov 25, 2024 1:14 PM Utah NHL team walks to arena after bus gets stuck in Toronto traffic Nov 25, 2024 12:47 PM US goalkeeper Alyssa Naeher is retiring from international soccer Nov 25, 2024 12:36 PM Featured Flyer

Missed kicks. Poor tackling. Costly penalties. Week 12 was filled with sloppy play around the NFL, leading to some upsets and surprising outcomes. Jayden Daniels nearly led Washington to an improbable comeback down 10 in the final two minutes against Dallas only to fall short because Austin Seibert's extra point sailed wide left. After a field goal and successful onside kick, Daniels connected with Terry McLaurin on an 86-yard catch-and-run touchdown to bring the Commanders within one point with 21 seconds remaining. But Seibert's point-after attempt failed and the Cowboys returned the ensuing onside kick for a touchdown to seal a 34-26 victory. Special teams were atrocious for both teams. Seibert also missed his first extra point and Washington allowed KaVontae Turpin's 99-yard kickoff return for a score earlier in the fourth quarter. The Cowboys missed a field goal, had another blocked and had a punt blocked. "What a wild special teams moment of blocked punts, kicks, kickoff returns, blocked field goals, just a number of things going to that spot," Commanders coach Dan Quinn said. Washington (7-5) was a 10 1/2-point favorite over the undermanned Cowboys (4-7) but ended up losing a third straight game. The Houston Texans were 8-point favorites against the lowly Tennessee Titans and let the game come down to Ka'imi Fairbairn missing a 28-yard field goal that would have tied it with just under two minutes left. C.J. Stroud threw two interceptions, was sacked four times and the Texans (7-5) committed 11 penalties, including an illegal shift that negated a go-ahead 33-yard TD pass to Nico Collins on the drive that ended with Fairbairn's miss in the 32-27 loss. The Titans (3-8) averaged just 17 points per game before putting 32 on the scoreboard against Houston's defense that entered No. 4 in the league. "We didn't do anything well enough to win this game," Texans coach DeMeco Ryans said. "Out of all the positives that we did have, there were way too many negatives. Too many negative plays. Score, get a penalty, get touchdowns called back. Get penalties on special teams. Just way too many negative plays defensively, like unexplainable explosives for touchdowns. We just didn't play good across the board." The San Francisco 49ers didn't have quarterback Brock Purdy, star edge rusher Nick Bosa and All-Pro left tackle Trent Williams against Green Bay. That was no excuse for their undisciplined performance. The Niners committed nine penalties and their tackling was shoddy in a 38-10 loss to the Packers. The defending NFC champions are 5-6 with a trip to Buffalo (9-2) coming up. They're still only one game behind Seattle and Arizona in the NFC West. "I'm really not concerned right now about how many guys were missing. We didn't play good enough, so that's not a factor. But, when you are missing some guys, you do have to be better. When you have those penalties and we didn't stop the run like we did and we had those three turnovers in the second half, that's how you get embarrassed." Coming off their first loss of the season, the two-time defending Super Bowl champion Chiefs needed Patrick Mahomes' heroics on the final drive to beat Carolina 30-27. Mahomes ran 33 yards to set up Spencer Schrader's 31-yard field goal as time expired. Kansas City had 10 penalties, including a pass interference that gave the Panthers (3-8) another chance to make the 2-point conversion that tied the game with 1:46 remaining. On defense, the Chiefs (10-1) suddenly shaky unit gave up 334 total yards against Bryce Young and an offense that entered last in the NFL. "We've got to do better. We're doing good in the red zone but that's only a third of the field," Chiefs safety Bryan Cook said. "We will go back and look at the film to see what we're doing week to week, and see the tendencies that we're giving up, and just move forward from there. At the end of the day, we're all vets in the room for the most part. ... got to go back to the drawing board and see what we're doing and correct it from there." The Vikings allowed the Bears to recover an onside kick with 21 seconds left and Caleb Williams followed with a 27-yard pass to D.J. Moore to set up Cairo Santos' tying 48-yard field goal. But Minnesota won in overtime, 30-27. The Chiefs and Vikings overcame their mistakes in narrow victories. The Commanders, Texans and 49ers couldn't. They have to be better down the stretch to make a playoff run. Get local news delivered to your inbox!Monolithic Power Systems, Inc. to Issue Quarterly Dividend of $1.25 (NASDAQ:MPWR)

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Tigers reportedly interested in seven-time All-StarThe new performance benchmarks showcase RNGD's ability to meet industry-leading throughput demands for Llama 3.1 models, including the 8B and 70B variants, with additional optimizations already in progress. The company also announced key software features that bring advanced optimization for customers currently sampling RNGD hardware in their production environments. These achievements represent the first phase of Furiosa's vision for AI infrastructure that overcomes the inherent limitations of GPUs. RNGD delivers winning throughput metrics with Llama 3.1 8B and 70B : Building on the AI-native Tensor Contraction Processor (TCP) architecture of RNGD , Furiosa is redefining real-world AI deployments, delivering unmatched performance, programmability, and power efficiency. Furiosa's RNGD recently achieved a throughput of 3,200–3,300 Tokens per Second (TPS) when running the LLaMA 3.1- 8B model. In single-user scenarios, RNGD consistently delivers 40–60 TPS performance. Additionally, RNGD demonstrates exceptional power efficiency, consuming 181W per card, with further optimization efforts underway. Rather than excessively boosting per-user performance, the company aims to maintain performance levels exceeding typical text-reading speeds (10–20 TPS or higher) while optimizing for multi-user environments and achieving a balanced performance approach. Furiosa is advancing the performance and efficiency of the LLaMA 3.1- 70B model. With just two RNGD cards, LLaMA 3.1- 70B can be executed effectively. Currently, a single server supports up to 100 concurrent user queries, with ongoing optimizations aiming to achieve 8,000 TPS per server when equipped with 8 RNGD cards. With the release of SDK v2024.3.0, Furiosa will expand the range of preloaded models. The SDK will also include support for tensor parallelism, enabling seamless processing across multiple elements without requiring model modifications, and a torch.compile, providing the foundation for executing customized models. Integration with HuggingFace Optimum will further empower customers to leverage a broader variety of models. Advanced optimization tools delivered to early RNGD customers: Building on these milestones, domestic and global enterprise customers are conducting tests with Furiosa to find a more efficient solution for scaling the inference of their self-developed models, compared to their existing setup. Their objective is to manage TCO effectively as they prepare for large-scale AI adoption. Furiosa plans to provide a high-quality AI development environment through a powerful and user-friendly SDK optimized for RNGD. The SDK v2024.1.0, currently available through the Early Access Program (EAP), is designed to handle high-performance processing of multiple LLM serving requests. It incorporates optimization techniques such as PagedAttention, Block KV Cache, and Continuous Batching, while also supporting various token sampling methods, including Greedy, Beam Search, and Top-k/p. These features allow developers to seamlessly create AI services customized to meet a wide range of requirements. The SDK and online sample will be available after the release of v2024.3.0. Furiosa remains committed to delivering the most sustainable AI deployment solutions through rigorous optimization at an unprecedented pace. "With RNGD now in customers' hands, we are accelerating the next generation of frontier LLMs to unlock emerging Agentic AI applications—bringing advanced reasoning capabilities to enterprise verticals, all at dramatically lower costs," said June Paik , Co-Founder and CEO of FuriosaAI. Furiosa Expands Global Footprint with Strategic Leadership Appointment Furiosa is scaling production and expanding its leadership team with the appointment of Alex Liu as Senior Vice President of Product and Business. A Technology Emmy Award winner and co-founder of NETINT Technologies, Alex brings over 20 years of expertise in startup management, technology innovation, and strategic leadership. At NETINT, he spearheaded groundbreaking achievements, including the development of the world's first VPU SoC, setting new industry benchmarks and securing the prestigious 2024 Technology Emmy Award. At Furiosa, Alex will lead global product management, go-to-market strategies, and partnerships to drive innovation and align the company's AI-native technologies with a vision to empower the development of planet-scale AI infrastructure. RNGD is currently sampling with customers, and mass production will ramp up in partnership with TSMC for 2025 availability. To learn more about Furiosa, please visit https://furiosa.ai/ . About FuriosaAI FuriosaAI is a semiconductor company dedicated to creating sustainable AI computing solutions that make powerful AI accessible to all. With its innovative Tensor Contraction Processor architecture, FuriosaAI is revolutionizing the AI hardware landscape, offering unparalleled efficiency and programmability for the most demanding AI workloads. For more information, please visit https://furiosa.ai/ . View original content to download multimedia: https://www.prnewswire.com/news-releases/furiosaai-ends-2024-on-a-high-note-llama-3-1-performance-sdk-release-leadership-expansion-302336756.html SOURCE FuriosaAI

Focus on technology & branding to promote tourism: Rajasthan Dy CMREC-617, a precision designed molecule, demonstrated dose-linear pharmacokinetics (PK) with rapid absorption and robust pharmacodynamic (PD) biomarker modulation, suggesting substantial target engagement Confirmed partial response (PR) observed during monotherapy dose-escalation in a patient with platinum-resistant ovarian cancer, treated with 4 lines of prior therapy in advanced setting, durable response ongoing after more than 6 months of treatment Additional 4 patients demonstrated a best response of stable disease (SD) for up to 6 months of treatment Plans to continue monotherapy dose escalation and initiate combination studies in 1H 2025 SALT LAKE CITY, Dec. 09, 2024 (GLOBE NEWSWIRE) -- Recursion (Nasdaq: RXRX) reported initial monotherapy dose-escalation data from the Phase 1/2 study (ELUCIDATE) of REC-617, a selective CDK7 inhibitor, in advanced solid tumors. These results were presented today after market close at an AACR Special Conference in Cancer Research. The company will also hold a webinar on December 10 at 6:30 AM MT / 8:30 AM ET / 1:30 PM GMT to present the preliminary data broadcast from Recursion’s X (formerly Twitter), LinkedIn, and YouTube accounts with an opportunity to submit questions here . "Cell cycle dysregulation and transcriptional 'addiction' are both hallmarks of many aggressive cancers," said David Hallett, Ph.D., Chief Scientific Officer of Recursion. "By inhibiting CDK7, we have the potential to target both mechanisms while fine tuning the therapeutic index. Using our precision design platform, we created a molecule with rapid oral absorption to reduce GI tissue exposure, a suitable half life to manage side effects, and target engagement covering the IC80 level." ELUCIDATE is an ongoing Phase 1/2 study evaluating the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and maximum tolerated dose (MTD) of REC-617 in patients with advanced solid tumors. As of the November 15, 2024 data cutoff, preliminary findings include 18 patients with advanced solid tumors who were response evaluable in the monotherapy dose-escalation phase. Doses ranged from 2 mg to 20 mg once daily (QD) and 1 mg twice daily (BID). REC-617 was generally well-tolerated across all dose levels, with no discontinuations due to adverse events (AEs). Adverse events to date were predominately Grade 1-2, on-target, and reversible. An MTD has not yet been reached. While efficacy was not an endpoint in this Phase 1 study, or anticipated in monotherapy, a confirmed durable partial response (PR) by RECIST on REC-617 monotherapy was achieved in a patient with metastatic, platinum-resistant ovarian cancer. The response is on-going after more than 6 months of treatment. This patient had progressed following 4 lines of prior therapy in the advanced setting. In addition, four patients achieved a best response of stable disease (SD) across multiple dose levels for up to 6 months of treatment. "These initial findings for REC-617 represent an exciting step forward in the development of CDK7 inhibitors, with a favorable PK/PD profile and a durable confirmed partial response observed in dose escalation in a highly pre-treated patient population," said Najat Khan, Ph.D., Chief R&D Officer and Chief Commercial Officer, Recursion. "Designed using our AI-powered OS platform, REC-617 reflects our focus on enhancing the therapeutic index to deliver more effective and safer treatment options for patients. We are eager to continue this momentum in dose escalation and to initiate the next phase of the program next year." In parallel to the ongoing monotherapy dose escalation (QD and BID), combination studies are expected to initiate for ELUCIDATE in H1, 2025. The company expects to present additional ELUCIDATE as well as preclinical REC-617 data at future medical meetings. Summary of Interim REC-617 Monotherapy Dose Escalation Results Study Design & Demographics Phase 1 monotherapy dose escalation in advanced solid tumors Data cutoff as of November 15, 2024 - 19 patients enrolled (18 response evaluable) Heavily pre-treated population (median of 4 prior lines of therapy in the advanced setting) Antiemetics and anti-diarrheals not mandated prophylaxis for nausea/vomiting/diarrhea PK/PD Summary REC-617 exceeds CDK7 IC80 with rapid absorption (Tmax 0.5–2 hours) with a half-life of 5-6 hours Early POLR2A 3-4x modulation suggests ~80–90% target engagement Quick, time-limited target engagement with POLR2A normalization in 24 hours Twice-daily (BID) dosing under investigation Safety Profile/AE Summary Adverse events (AEs) were predominantly low grade, on-target, and reversible upon treatment cessation Early data indicates a favorable safety profile – maximum tolerated dose (MTD) not reached No treatment discontinuations due to AEs 3 treatment related serious adverse events (SAE)s reported in 2/19 patients Events resolved and treatment continued after dose reduction Antiemetics and anti-diarrheals not mandated prophylaxis for nausea/vomiting/diarrhea Confirmed Partial Response & Stable Disease Summary One confirmed partial response (PR) by RECIST 1.1 (decrease of more than 30% in the sum of the longest diameters of target lesions + no new lesions + no progression of non target lesions) Partial response (-34%) achieved with reduction of 2 lymph nodes (para-aortic and mesenteric) at Week 16 with normalization of LDH Reduction of tumor marker CA125 from 1249 to 694 kU/L (-44%) Reduction of tumor marker TK1 from 174 to 56 DuA (-68%) Response ongoing after more than 6 months of treatment Patient continues study therapy without need for antiemetics Four additional patients achieved durable (up to 6 months of treatment) response of stable disease (SD) as best response across multiple dose levels All four patients progressed prior to entering the study Three CRC patients (6L-7L) and one NSCLC patient (4L) One patient on 2mg QD and three patients on 10mg QD About REC-617 REC-617 is a potential best-in-class CDK7 inhibitor, precision designed using AI-led approaches, with only 136 novel molecule synthesized from hit to candidate identification in less than 12 months. The molecule is designed to maximize its therapeutic index by enabling the tight control of both the extent and duration of target inhibition. CDK7 inhibition combines many potential benefits such as transcription inhibition, reduction of aberrant kinome activation, cell cycle inhibition, and modulation of estrogen receptor activity. This makes it an attractive target to overcome common resistance pathways associated with CDK4/6 inhibition, which only targets the cell cycle. About ELUCIDATE REC-617 is currently being evaluated as a monotherapy in the ELUCIDATE trial. ELUCIDATE is a multicenter, open-label, two-stage clinical trial to evaluate safety, pharmacokinetics, pharmacodynamics, and efficacy of REC-617 in advanced solid tumors, including non-small cell lung cancer (NSCLC), colorectal cancer, breast cancer, pancreatic cancer, ovarian cancer, head and neck cancer. Both the monotherapy and combination therapy dose escalation portion of the trial will enroll patients across multiple dose levels to determine the optimal biological dose (OBD). The dose expansion phase of the trial will commence upon identification of the OBD. The primary efficacy endpoint of the expansion phase is objective response rate (ORR). About Recursion Recursion (NASDAQ: RXRX) is a clinical stage TechBio company leading the space by decoding biology to radically improve lives. Enabling its mission is the Recursion OS, a platform built across diverse technologies that continuously generate one of the world’s largest proprietary biological and chemical datasets. Recursion leverages sophisticated machine-learning algorithms to distill from its dataset a collection of trillions of searchable relationships across biology and chemistry unconstrained by human bias. By commanding massive experimental scale — up to millions of wet lab experiments weekly — and massive computational scale — owning and operating one of the most powerful supercomputers in the world, Recursion is uniting technology, biology and chemistry to advance the future of medicine. Recursion is headquartered in Salt Lake City, where it is a founding member of BioHive, the Utah life sciences industry collective. Recursion also has offices in Toronto, Montréal, New York, London, Oxford area, and the San Francisco Bay area. Learn more at www.Recursion.com , or connect on X (formerly Twitter) and LinkedIn. Media Contact Media@Recursion.com Investor Contact Investor@Recursion.com Forward-Looking Statements This document contains information that includes or is based upon “forward-looking statements” within the meaning of the Securities Litigation Reform Act of 1995, including, without limitation, those regarding the potential efficacy of REC-617; timing of the Phase 1/2 clinical trial of REC-617; early and late stage discovery, preclinical, and clinical programs; licenses and collaborations; prospective products and their potential future indications and market opportunities; Recursion OS and other technologies; business and financial plans and performance; and all other statements that are not historical facts. Forward-looking statements may or may not include identifying words such as “plan,” “will,” “expect,” “anticipate,” “intend,” “believe,” “potential,” “continue,” and similar terms. These statements are subject to known or unknown risks and uncertainties that could cause actual results to differ materially from those expressed or implied in such statements, including but not limited to: challenges inherent in pharmaceutical research and development, including the timing and results of preclinical and clinical programs, where the risk of failure is high and failure can occur at any stage prior to or after regulatory approval due to lack of sufficient efficacy, safety considerations, or other factors; our ability to leverage and enhance our drug discovery platform; our ability to obtain financing for development activities and other corporate purposes; the success of our collaboration activities; our ability to obtain regulatory approval of, and ultimately commercialize, drug candidates; our ability to obtain, maintain, and enforce intellectual property protections; cyberattacks or other disruptions to our technology systems; our ability to attract, motivate, and retain key employees and manage our growth; inflation and other macroeconomic issues; and other risks and uncertainties such as those described under the heading “Risk Factors” in our filings with the U.S. Securities and Exchange Commission, including our Annual Report on Form 10-K and Quarterly Reports on Form 10-Q. All forward-looking statements are based on management’s current estimates, projections, and assumptions, and Recursion undertakes no obligation to correct or update any such statements, whether as a result of new information, future developments, or otherwise, except to the extent required by applicable law.

Playoff game at Ohio State has sold 34% more tickets than Notre Dame game on StubHubKINGSTON, R.I. (AP) — Sebastian Thomas' 19 points helped Rhode Island defeat Providence 69-63 on Saturday. Thomas shot 7 for 14 (3 for 5 from 3-point range) and 2 of 3 from the free-throw line for the Rams (9-0). Jaden House scored 18 points and added five rebounds. David Green shot 4 for 11 (1 for 3 from 3-point range) and 3 of 4 from the free-throw line to finish with 12 points, while adding eight rebounds and three blocks. The Friars (6-4) were led in scoring by Bryce Hopkins, who finished with 16 points, eight rebounds and three steals. Bensley Joseph added 16 points and two steals for Providence. Jayden Pierre also had 12 points and three steals. House scored 14 points in the first half and Rhode Island went into halftime trailing 35-28. Thomas scored 17 points down the stretch in the second half to help lead Rhode Island to a six-point victory. NEXT UP Both teams next play Tuesday. Rhode Island visits Brown and Providence squares off against DePaul on the road. The Associated Press created this story using technology provided by Data Skrive and data from Sportradar .

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Trending News Today Live Updates: In today's fast-paced world, staying informed about the latest developments is more important than ever. Trending News Today brings you the most current and impactful stories from across the globe, covering a wide range of topics including politics, technology, entertainment, sports, and social issues. Whether it's a significant political event, a groundbreaking technological innovation, or the latest in pop culture, we provide you with up-to-the-minute updates and in-depth analysis. Our goal is to ensure that you're always in the loop, aware of the trends that are shaping the world around us. Stay tuned for the latest news that matters. Trends News Today Live: The Spencer Stare: Royal fans obsessed with William, Charlotte, and George’s striking resemblance to DianaTEMPE, Ariz. (AP) — Caleb McCullough was there for the dark times at Arizona State, when the losses piled up and the cloud of an NCAA investigation was hovering over the program. The senior linebacker opted to stick around, believing in coach Kenny Dillingham's vision for a better future. It came sooner than anyone outside the program expected. "I’m doing whatever I can to win,” McCullough said. “I’m not really a stat player. This is my last year of college and my main goal is just to win.” The Sun Devils are doing just that, becoming one of college football's biggest surprises along the way. Picked to finish last in its first Big 12 season, Arizona State (8-2, 5-2 Big 12) now controls its destiny for a spot in the conference title game. The 21st-ranked Sun Devils have already clinched their first bowl berth since 2021, the year they were last ranked in the AP Top 25 before this week. Arizona State has taken down two ranked teams this season, 27-19 over then-No. 16 Utah on Oct. 11 and 24-14 at then-No. 20 Kansas State last weekend. The Sun Devils will play their biggest home game in recent memory against No. 14 BYU on Saturday , the first home game between ranked teams in Tempe since 2014. Beat the Cougars and Arizona State can clinch a spot in the Big 12 Championship on Dec. 7 in Arlington, Texas, with a win over rival Arizona in the regular-season finale. “It means a lot to these guys to come in here with that chip on their shoulder and do something that really nobody thought we could do,” Dillingham said. Arizona State faced adversity on and off the field when Dillingham arrived in 2023. After winning eight games in 2021, the Sun Devils went 3-9 the following year while under investigation by the NCAA, a combination that led to the firing of Herm Edwards during his fifth season here. Dillingham had success as Oregon's offensive coordinator and brought the requisite enthusiasm of being a young — he was 32 at the time — first-time head coach returning to his alma mater. Despite rallying the community around the program, Dillingham fell into hard luck his first season in the desert. The Sun Devils were decimated by injuries, particularly at quarterback, and never recovered, finishing 3-9 for the second straight season. But Dillingham had the pieces in place. He proved to be adept at finding the right players through the transfer portal, landing former Sacramento State running back Cam Skattebo two years ago and former Michigan State quarterback Sam Leavitt prior to this season. The hard-running Skattebo has been one of the nation's best running backs and Leavitt has been a perfect fit for Arizona State's offense, making good decisions while extending plays with his legs. The portal success extends across Arizona State's roster and Dillingham has sprinkled in solid recruiting classes while convincing key players to remain, a combination that's meshed into a team that could crash the College Football Playoff if the pieces fall just right. “We were a three-win team twice,” Dillingham said. “We were under NCAA sanctions. Most head coaches, to be brutally honest, get fired if you take a job under sanctions. You don’t survive. You’re hired to be fired. That’s the nature of the beast and right now we’re sitting here at 8-2, and I couldn’t be prouder." Dillingham's vision for a better future, one the rest of the country didn't see coming, is here and now. AP college football: https://apnews.com/hub/ap-top-25-college-football-poll and https://apnews.com/hub/college-football

Recent viral assault video in Kelowna took place over a year ago: RCMPWhat to know about Scott Turner, Trump's pick for housing secretaryAttorneys for Donald Trump conducted an internal investigation into allegations that one of his top aides, Boris Epshteyn, has sought to gain financially from his influence with Trump and others in the president-elect’s orbit, according to multiple sources familiar with the matter. The internal investigation, which was confirmed by half a dozen sources and is not criminal in nature, has probed multiple instances of Epshteyn allegedly requesting payment in exchange for promoting candidates for administration positions or offering to connect individuals with people in the upcoming administration relevant to their industries, sources said. In one instance he requested as much as $100,000 per month in exchange for his services, according to sources familiar with the matter. Epshteyn’s alleged activities prompted those looking into the matter to make an initial recommendation that Epshteyn should be removed from Trump’s proximity and that he should not be employed or paid by Trump entities, according to two sources. As of Monday afternoon, it does not appear the transition team will heed that recommendation. “I am honored to work for President Trump and with his team,” Epshteyn said in a statement to CNN. “These fake claims are false and defamatory and will not distract us from Making America Great Again.” The alleged behavior by one of Trump’s closest advisers hints at some of the turmoil and strife behind the scenes of the transition process as the president-elect and his team staff the incoming administration. Epshteyn, long seen as one of Trump’s most loyal advisers, has played a significant role in the transition, sitting in on key meetings and candidate briefings at the president-elect’s Mar-a-Lago resort in Palm Beach, Florida. But his presence has often been a divisive one. A notorious Trump-world infighter, Epshteyn is known for his combative and loud personality, and often boasts about his close relationship with Trump, according to sources in and around the president-elect’s orbit. In recent years, Epshteyn has acted as both an attorney and an adviser to Trump and – much to the chagrin of some more experienced lawyers in Trump’s inner circle– played an influential role in organizing his criminal defense strategy after the former president was indicted four times. While Epshteyn has not been accused of illegal behavior, the decision to launch an internal investigation reflects the Trump team’s cautiousness around activity that could appear unsavory. “As is standard practice, a broad review of the campaign’s consulting agreements has been conducted and completed, including as to Boris, among others,” Trump transition spokesman Steven Cheung said in a statement to CNN. “We are now moving ahead together as a team to help President Trump Make America Great Again.” Source: ‘Very much pay-for-play’ Part of that investigation focused on claims that Epshteyn proposed that Scott Bessent, Trump’s pick for Treasury secretary, pay him to promote his name with Trump and others at Mar-a-Lago. Bessent did not make payments to Epshteyn. CNN has reached out to representatives of Bessent for comment. The back-and-forth between Epshteyn and Bessent resulted in a heated confrontation last week in the lobby of Mar-a-Lago, where Epshteyn raised his voice at Bessent, according to two sources briefed on the matter. In at least one other instance, Epshteyn asked for payment in exchange for introductions and influence with the incoming Trump administration, according to two sources. Trump’s legal team was investigating several other similar alleged incidents, according to sources familiar with the situation. The allegations concerning Epshteyn were brought to incoming White House chief of staff Susie Wiles, two sources familiar with the matter told CNN. It is unclear whether the allegations have been presented to Trump directly. At times, Epshteyn has described the services he is trying to sell as a type of consulting, but the legal team investigating the issue has struggled to pinpoint any legitimate consulting work Epshteyn has provided, according to a source familiar with the matter. “The way I see it is it’s very much a pay-for-play,” said one person who spoke to the legal team that investigated Epshteyn. This person described a separate incident in which Epshteyn allegedly tried to request payment for questionable consulting services, offering to connect the person with incoming administration officials relevant to their industry or lobbying firms that will be the most well-connected to the new administration. The investigator assured the person that their interaction with Epshteyn wasn’t an isolated incident. “It was like, ‘Hey, you’re not the only one,’” the person who spoke to investigators said. “He’s gone to everybody for it.” One person close to Epshteyn brushed off the notion that this was pay-for-play. “This is how Washington works,” the person said. Allies of Epshteyn described the internal review as the product of newer associates not understanding the dynamic between Trump and Epshteyn as well as a disdain for the power Epshteyn wields with the President-elect. Epshteyn was a constant presence on Trump’s plane through the end of the 2024 campaign, often insisting on being present for conversations and briefings that had nothing to do with legal matters, a source close to Trump told CNN. “Boris is a Trump original—loyal and effective from the very beginning,” a Trump transition official told CNN. “He works for President Trump, and nobody else, and has helped defeat the most vicious lawfare campaign in history. Boris has seen these petty skirmishes before, but he always perseveres.” Lobbied for Gaetz As the legal team’s investigation got underway, Epshteyn sent cease-and-desist-style messages to associates, claiming he had never demanded payment and threatening legal action, according to two people familiar with the matter. Epshteyn has long been a fixture of the president-elect’s inner circle and has been part of key meetings with Trump at Mar-a-Lago during the transition period. He is often spotted at Mar-a-Lago eating dinner with the president-elect on the patio and has sat in on several transition meetings and candidate briefings, particularly related to Trump’s choices for the Department of Justice. Sources described Epshteyn as responsible for pushing former Florida Rep. Matt Gaetz’s name amid discussions about who Trump should pick as his attorney general. Epshteyn lobbied for Gaetz directly to Trump on a flight just hours before Gaetz was named as the pick. The former Florida congressman later withdrew after it became clear he didn’t have the votes in the Senate amid the potential disclosure of a House Ethics Committee report detailing an investigation into Gaetz, including over allegations of sexual misconduct and other alleged crimes. Confrontation with Musk Despite a seemingly more orderly and quick process than in 2016, Trump’s transition this time around is still rife with the infighting that is typically on display in Trump’s orbit, multiple sources familiar with the matter tell CNN. Sources on the transition team have expressed frustration at how many people have Trump’s ear and how quickly a day’s progress can be undone. Tensions between Epshteyn and some other members of Trump’s inner circle have escalated in recent weeks. Elon Musk, who has been by Trump’s side regularly since the election and has a growing influence on the president-elect, has questioned Epshteyn’s sway over Trump. The two also had a confrontation at Mar-a-Lago, with Musk leveling a number of accusations at Epshteyn, according to two sources familiar with the matter. This year, the Trump campaign paid Epshteyn’s firm, Georgetown Advisory, $53,500 each month for communications and legal consulting, according to campaign finance records through October, the most recent month available. Epshteyn briefly served in the first Trump administration as a special assistant to the president in 2017, but he has not been offered a formal role in the incoming administration. Epshteyn stood alongside Trump during his arraignment in his New York hush money case and traveled with him for his arraignments in Georgia and Washington, DC. Epshteyn himself faces criminal charges in a case in Arizona related to efforts to upend the results of the 2020 presidential election. He has pleaded not guilty.

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Opinion editor’s note: Strib Voices publishes a mix of commentary online and in print each day. To contribute, click here . ••• The long lines on election days across countries and continents suggest dynamic democracies. But despite the calendar aligning for a record-setting number of people worldwide eligible to vote this year, democracy itself is actually imperiled. That’s the clear conclusion from Freedom House, which said in its annual “ Freedom in the World ” report that “flawed elections and armed conflicts contributed to the 18th year of democratic decline.” The “breadth and depth of the deterioration was extensive,” the think tank reported, adding that “political rights and civil liberties were diminished in 52 countries, while only 21 countries saw improvements.” That analysis was amplified in a similarly grim report from the Economist Intelligence Unit, which starkly stated that “conflict and polarization drive a new low for global democracy.” This dire data corresponds with, and may have been caused by, a commensurate retreat in media freedom, as evidenced by Reporters Without Borders’ annual World Press Freedom Index , which warned that “press freedom around the world is being threatened by the very people who should be its guarantors — political authorities.” Indeed, if democracy were a stock, “it would have suffered something of a price correction over the last 20 years,” said Richard Haass , the president emeritus of the Council on Foreign Relations. Haass, a veteran envoy who served Republican and Democratic administrations, was speaking via video on Tuesday night at a Minnesota Peace Initiative forum called “The World Votes: Global Democracy at a Crossroads.” The event, held in Minneapolis at Norway House (fitting, considering Norway held the top spot in the World Press Freedom Index and along with fellow Scandinavian nations is ranked as the world’s most free by Freedom House), drew a capacity crowd with many more online to hear from Haass, me and three other panelists: Chad Vickery , vice president of global strategy and technical leadership at the International Foundation for Electoral Systems; Aram Gavoor , a former Justice Department official and current professor at the George Washington University Law School; and Thomas Hanson , diplomat-in-residence at the University of Minnesota Duluth. Haass cited several factors for his clear-eyed diagnosis of democracy, including technological transformations that have ushered in an unsettled media landscape. “We live in one of the odd moments in history where there’s never been greater access to information and never been greater access to disinformation,” Haass said, adding that citizens don’t know if information is “accurate, fully accurate, partially accurate or essentially inaccurate.” That’s to autocrats’ advantage, asserted Gavoor, who said that this country’s competitors “have sought to exploit the U.S. democratic system for quite some time.” The “age of technology, especially with social media,” he said, has “taken on a dramatically different dimension.” Mentioned as additional direct democratic threats were distributed denial-of-service attacks and “strategic foreign mis- and disinformation campaigns that oftentimes are quite opportunistic and play on various doubts in the minds of Americans.” Gavoor gave this good news, however: “The federal government has actually gotten quite adept and capable with regard to identifying foreign mis- and disinformation to the extent that there are significant bodies that exist to combat these things,” like the National Security Council and the Office of the Director of National Intelligence. But the threat to democracy from domestic disinformation is an even greater challenge, Gavoor said. And, he added, wherever the disinformation originates, the objective is similar. “Keep in mind that the end goal is not just to disrupt an American election or to cause a particular candidate to be advantaged or not. The end goal is to undermine the entire system of American governance and the faith in American democracy and perhaps greater softening of the resolve to maintain a democracy.” Disinformation is just one component corroding democratic norms within some countries, said Vickery. “We’ve learned how autocracy works: First, you have to win an election by popular vote, usually running against the elites in your country.” Next, he said, “you change the election laws, you game the system to make sure you can win again and not be challenged again.” “But then the third thing is you need to harass civil society in many places” — places like Norway House, he said. “After that, you need to pack the courts with judges who are going to support you, and then you want to enrich your cronies with corruption and then you buy up newspapers and television and make this propaganda machine.” If the democracy-tending attendees at Norway House were any indication, that’s not about to happen here. Indeed, the citizen engagement on display was considered a model by moderator Janet Dolan, who co-created the Minnesota Peace Initiative with her husband, William Moore. The other panelists concurred on Dolan’s admiration, and that along with a free press, such civic involvement should be inviolate in this country and the others it tries to inspire toward a democratic form of government. But the beacon that former Foreign Service officers like Hanson projected and protected on behalf of this country may not shine as bright in recent years. “I think many people in the world perceive that the American model of democracy is less compelling than it was, and that makes our work globally much more challenging,” said Hanson, who added, “and we’re beginning to see other narratives of contestation on democracy and on elections.” Hanson, who will hold his highly anticipated and attended Global Minnesota “ 2025 U.S. Foreign Policy Update ” on Jan. 23, began by saying he was “struck by the dichotomy between an agreed ‘recession of democracy’ and an unprecedented number of elections” this year. “I think that shows how elections nowadays are being used to legitimize variants of democracy.” Many “managed democracies around the world hold elections if they predetermine who can participate. This is the case in Russia. This is the case in Pakistan.” And, he added, “I hate to say it, but at the local level in our own country our two parties go to great lengths to prevent any third-party candidate from participating, which is a minor example of what I’m describing.” According to Vickery, those democracies, however managed or free and fair, have had results that can be categorized as “change-of-status elections” like in the U.S., U.K., South Africa, North Macedonia, Botswana, Senegal and others. Next are elections “solidifying power,” such as in Indonesia and Mexico. And more hopefully, there are examples of “bounce-back” democracies that through elections or civic action have gone “in the right direction,” including Sri Lanka and Bangladesh. While not as many will queue to choose their leaders next year, Vickery noted that there will be 102 elections in 68 nations affecting 1.2 billion citizens worldwide. So for many, 2025 will truly be an election year, even if globally it isn’t quite a year of elections like 2024. But democracy “is about more than voting,” said Haass. “We the citizens, we the people, have the obligation, and I would argue the self-interest, to exercise our democratic rights, to stay informed, to stay involved, and to make sure that those who are entrusted with outsized political power comport themselves and act consistent with the law, and act consistent with the norms that make our democracy what it is.” What it is can be credited in no small part to the kind of civil, civic engagement from groups like the Minnesota Peace Initiative and the involved, inspiring citizens attending Tuesday’s event.

BURLINGTON, N.J., Nov. 26, 2024 (GLOBE NEWSWIRE) -- Burlington Stores, Inc. (NYSE: BURL), a nationally recognized off-price retailer of high-quality, branded apparel, footwear, accessories, and merchandise for the home at everyday low prices, announced today that Shira Goodman, former Chief Executive Officer of Staples, Inc., is joining its Board of Directors and its Audit Committee effective January 1, 2025. John Mahoney, Chairman of the Board, stated, “We are very pleased to welcome Shira to our Board as a highly accomplished business leader with considerable public company board experience. I believe that she will enhance the depth and strength of our Board as it continues to oversee the Company’s continued strategic growth.” Michael O’Sullivan, Chief Executive Officer, stated, “We are very excited to have Shira as a Board member. She has almost three decades of experience in the retail industry, and her perspectives and expertise will benefit us as we continue to execute on the Burlington 2.0 strategy and aim to drive sales and earnings growth in the years ahead.” Ms. Goodman added, “I am excited to join Burlington’s Board and work with the leadership team. I believe the Company is well positioned for continued growth and I am eager to contribute to the Company's continued success.” About Shira Goodman Ms. Goodman has served as an Advisory Director to Charlesbank Capital Partners, a private equity firm, since January 2019. She previously served as the Chief Executive Officer of Staples, Inc. from September 2016 to January 2018. Ms. Goodman served in roles with increasing responsibility at Staples since joining the company in 1992, including President and Interim Chief Executive Officer from June 2016 to September 2016, President, North American Operations from January 2016 to June 2016, and President, North American Commercial from February 2014 to June 2016. Prior to that, she served as Executive Vice President of Global Growth from February 2012 to February 2014, Executive Vice President of Human Resources from March 2009 to February 2012, Executive Vice President of Marketing from May 2001 to March 2009, and in various other management positions. Prior to Staples, Ms. Goodman worked at Bain & Company from 1986 to 1992, in project design, client relationships and case team management. She currently serves on the board of directors of CarMax, Inc. and CBRE Group, Inc., and previously served on the board of directors of Henry Schein, Inc., Staples, Inc. and The Stride Rite Corporation. About Burlington Stores, Inc. Burlington Stores, Inc., headquartered in New Jersey, is a nationally recognized off-price retailer with Fiscal 2023 net sales of $9.7 billion. The Company is a Fortune 500 company and its common stock is traded on the New York Stock Exchange under the ticker symbol “BURL.” The Company operated 1,103 stores as of the end of the third quarter of Fiscal 2024, in 46 states, Washington D.C. and Puerto Rico, principally under the name Burlington Stores. The Company’s stores offer an extensive selection of in-season, fashion-focused merchandise at up to 60% off other retailers' prices, including women’s ready-to-wear apparel, menswear, youth apparel, baby, beauty, footwear, accessories, home, toys, gifts and coats. For more information about the Company, visit www.burlington.com . Investor Relations Contacts: David J. Glick Daniel Delrosario 855-973-8445 Info@BurlingtonInvestors.com Allison Malkin ICR, Inc. 203-682-8225 Safe Harbor for Forward-Looking and Cautionary Statements This release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. All statements other than statements of historical fact included in this release are forward-looking statements. Forward-looking statements discuss our current expectations and projections relating to our financial condition, results of operations, plans, objectives, future performance and business. You can identify forward-looking statements by the fact that they do not relate strictly to historical or current facts. We do not undertake to publicly update or revise our forward-looking statements, except as required by law, even if experience or future changes make it clear that any projected results expressed or implied in such statements will not be realized. If we do update one or more forward-looking statements, no inference should be made that we will make additional updates with respect to those or other forward-looking statements. All forward-looking statements are subject to risks and uncertainties that may cause actual events or results to differ materially from those we expected, including general economic conditions, such as inflation, and the domestic and international political situation and the related impact on consumer confidence and spending; competitive factors, including the scale and potential consolidation of some of our competitors, rise of e-commerce spending, pricing and promotional activities of major competitors, and an increase in competition within the markets in which we compete; seasonal fluctuations in our net sales, operating income and inventory levels; the reduction in traffic to, or the closing of, the other destination retailers in the shopping areas where our stores are located; our ability to identify changing consumer preferences and demand; our ability to meet our environmental, social or governance (“ESG”) goals or otherwise expectations of our stakeholders with respect to ESG matters; extreme and/or unseasonable weather conditions caused by climate change or otherwise adversely impacting demand; effects of public health crises, epidemics or pandemics; our ability to sustain our growth plans or successfully implement our long-range strategic plans; our ability to execute our opportunistic buying and inventory management process; our ability to optimize our existing stores or maintain favorable lease terms; the availability, selection and purchasing of attractive brand name merchandise on favorable terms; our ability to attract, train and retain quality employees and temporary personnel in sufficient numbers; labor costs and our ability to manage a large workforce; the solvency of parties with whom we do business and their willingness to perform their obligations to us; import risks, including tax and trade policies, tariffs and government regulations; disruption in our distribution network; our ability to protect our protect our information systems against service interruption, misappropriation of data, breaches of security, or other cyber-related attacks; risks related to the methods of payment we accept; the success of our advertising and marketing programs in generating sufficient levels of customer traffic and awareness; damage to our corporate reputation or brand; impact of potential loss of executives or other key personnel; our ability to comply with existing and changing laws, rules, regulations and local codes; lack of or insufficient insurance coverage; issues with merchandise safety and shrinkage; our ability to comply with increasingly rigorous privacy and data security regulations; impact of legal and regulatory proceedings relating to us; use of social media by us or by third parties our direction in violation of applicable laws and regulations; our ability to generate sufficient cash to fund our operations and service our debt obligations; our ability to comply with covenants in our debt agreements; the consequences of the possible conversion of our convertible notes; our reliance on dividends, distributions and other payments, advance and transfers of funds from our subsidiaries to meet our obligations; the volatility of our stock price; the impact of the anti-takeover provisions in our governing documents; impact of potential shareholder activism; and each of the factors that may be described from time to time in our filings with the U.S. Securities and Exchange Commission, including under the heading “Risk Factors” in our most recent Annual Report on Form 10-K. For each of these factors, the Company claims the protection of the safe harbor for forward-looking statements contained in the Private Securities Litigation Reform Act of 1995, as amended.

QB Josh Allen and coach Sean McDermott deserve credit in Bills latest AFC East-clinching season

HP Study: Why Work Isn’t Working And What Can Fix ItUkraine must be placed in the “strongest possible position for negotiations” to end the war with Russia, Sir Keir Starmer has said. The Prime Minister insisted the UK will back Ukraine “for as long as it takes” as he made a speech at the Lord Mayor’s Banquet in London, but for the first time acknowledged the conflict could move towards a negotiated end. Ukrainian President Volodymyr Zelensky has in recent weeks suggested he is open to a possible ceasefire with Vladimir Putin’s Russia. Kyiv and its European allies meanwhile fear the advent of Donald Trump’s return to the White House could result in American aid being halted. President-elect Trump has said he would prefer to move towards a peace deal, and has claimed he could end the conflict on “day one” of his time in power. As he attempts to strike up a good relationship with the incoming president, Sir Keir revealed he had told Mr Trump the UK “will invest more deeply than ever in this transatlantic bond with our American friends in the years to come”. In his speech at London’s Guildhall, the Prime Minister said there is “no question it is right we support Ukraine”, as the UK’s aid to Kyiv is “deeply in our self-interest”. Allowing Russia to win the war would mean “other autocrats would believe they can follow Putin’s example,” he warned. Sir Keir added: “So we must continue to back Ukraine and do what it takes to support their self-defence for as long as it takes. “To put Ukraine in the strongest possible position for negotiations so they can secure a just and lasting peace on their terms that guarantees their security, independence, and right to choose their own future.” Mr Zelensky told Sky News over the weekend he would be open to speaking with Mr Putin, but branded the Russian president a “terrorist”. He also suggested Ukrainian territory under his control should be taken under the “Nato umbrella” to try to stop the “hot stage” of the war with Russia. In a banquet speech focused on foreign affairs, the Prime Minister said it was “plain wrong” to suggest the UK must choose between its allies, adding: “I reject it utterly. “(Clement) Attlee did not choose between allies. (Winston) Churchill did not choose. “The national interest demands that we work with both.” Sir Keir said the UK and the US were “intertwined” when it came to commerce, technology and security. The Prime Minister added: “That’s why, when President Trump graciously hosted me for dinner in Trump Tower, I told him that we will invest more deeply than ever in this transatlantic bond with our American friends in the years to come.” He also repeated his commitment to “rebuild our ties with Europe” and insisted he was right to try to build closer links with China. “It is remarkable that until I met President Xi last month there had been no face-to-face meeting between British and Chinese leaders for six years,” the Prime Minister said. “We can’t simply look the other way. We need to engage. To co-operate, to compete and to challenge on growth, on security concerns, on climate as well as addressing our differences in a full and frank way on issues like Hong Kong, human rights, and sanctions on our parliamentarians,” he added. The Prime Minister said he wants Britain’s role in the world to be that of “a constant and responsible actor in turbulent times”. He added: “To be the soundest ally and to be determined, always, in everything we do. “Every exchange we have with other nations, every agreement we enter into to deliver for the British people and show, beyond doubt, that Britain is back.” Ahead of Sir Keir’s speech, Lord Mayor Alastair King urged the Prime Minister and his Government to loosen regulations on the City of London to help it maintain its competitive edge. In an echo of Sir Keir’s commitment to drive the UK’s economic growth, the Lord Mayor said: “The idealist will dream of growth, but the pragmatist understands that our most effective machinery to drive growth is here in the City, in the hands of some of the brightest and most committed people that you will find anywhere in the world.”

TALLINN, Estonia (AP) — Belarus has granted asylum to a former Polish judge who faced espionage charges at home following his defection in May to the Kremlin-allied country. Read this article for free: Already have an account? To continue reading, please subscribe: * TALLINN, Estonia (AP) — Belarus has granted asylum to a former Polish judge who faced espionage charges at home following his defection in May to the Kremlin-allied country. Read unlimited articles for free today: Already have an account? TALLINN, Estonia (AP) — Belarus has granted asylum to a former Polish judge who faced espionage charges at home following his defection in May to the Kremlin-allied country. A decree published Friday by Alexander Lukashenko, Belarus’ autocratic president, described Tomasz Szmydt as being “prosecuted for political reasons” in Poland. The country is an EU and NATO member that has lent vocal support to Ukraine in its war against Russian aggression. Szmydt’s defection to Belarus in May trained the focus on Poland as a key target for Russian intelligence activity and ignited a bitter political row over the circumstances of his rapid ascent through the ranks of the Polish justice system. Poland’s prosecutors and special services launched an investigation the same month after Belarus media reported that Szmydt arrived in the country and asked for protection. Warsaw responded days later by putting Szmydt on a wanted list, a step toward an international arrest warrant on spying allegations that would restrict his ability to travel internationally. Polish officials have been working to determine how harmful Szmydt’s knowledge of any classified information might be to the interests of Warsaw and its Western allies. Poland’s Prime Minister Donald Tusk has publicly called him a traitor. Szmydt fled to Belarus after resigning from his post as a judge at the Warsaw Administrative Court, saying in a public statement that he was doing so in protest against Poland’s “harmful and unjust” policy toward Belarus and Russia. A short time later, he appeared at a press conference in Belarus, praising Lukashenko’s regime and presenting himself as a victim of repression. A Polish court later that month lifted Szmydt’s immunity, allowing him to be tried in absentia for spying allegations that he has denied. Winnipeg Jets Game Days On Winnipeg Jets game days, hockey writers Mike McIntyre and Ken Wiebe send news, notes and quotes from the morning skate, as well as injury updates and lineup decisions. Arrives a few hours prior to puck drop. Szmydt was notorious in Poland for having engaged in a 2019 online smear campaign against other judges that was sponsored by the Justice Ministry under the previous right-wing government. Three years later, he appeared to switch sides, appearing in a TV documentary to expose what he said was unethical behavior by judges close to the ruling party. Szmydt’s defection came as a shock in Poland, which has a history of distrust of Russia. Belarus has been one of the Kremlin’s few close allies since Russia’s full-scale invasion of Ukraine in February 2022, and Lukashenko has relied on Moscow’s subsidies and support. In return, he has allowed Moscow to use Belarusian territory to send troops and weapons into the neighboring state, and to deploy tactical nuclear weapons on Belarusian soil. Authorities in Minsk have been ratcheting up repressive measures ahead of a presidential election in January in which the strongman leader is seeking a seventh term, including by arresting hundreds of people who have shown solidarity with Kyiv. Authorities responded to massive protests following the widely disputed 2020 election of Lukashenko with a wide-ranging crackdown in which about 65,000 people were arrested. Major opposition figures were either imprisoned or fled the country, and human rights activists say Belarus is holding about 1,300 political prisoners. Advertisement AdvertisementGiants receiver Malik Nabers could miss Saints game after MRI confirms hip flexor

NICEVILLE, Fla. (AP) — Aaliyah Nye scored 15 points and No. 23 Alabama coasted to an 83-33 win over Alabama State on Monday at the Emerald Coast Classic. Sarah Ashlee Barker and Karly Weathers both added 12 points for the Crimson Tide (7-0). Zaay Green had 11. Barker, Weathers and Green combined to go 12 of 16 from the field as Alabama shot 51% and made 23 of 34 free throws. Cordasia Harris had eight points for the Hornets (2-3), who shot 27.5% and had 28 turnovers while being outrebounded by 17. Alabama entered ranked 17th in scoring offense through the first two weeks of the season, averaging 87.3 points per game. Barker opened the scoring and contributed another layup before her 3-pointer made it 14-0. The Tide led 26-8 after one quarter. Alabama also had a 13-2 run in the second quarter and Weathers had a buzzer-beating 3-pointer to lead 46-20 at halftime. Alabama plays the winner of UAB-Clemson on Tuesday and the Hornets face the loser. ___ Get poll alerts and updates on the AP Top 25 throughout the season. Sign up here . AP women’s college basketball: https://apnews.com/hub/ap-top-25-womens-college-basketball-poll and https://apnews.com/hub/womens-college-basketballExperts discuss why and how to navigate information overload and counter misinformation so that people with cancer can make well-informed decisions about their care. WASHINGTON , Dec. 6, 2024 /PRNewswire/ -- The National Comprehensive Cancer Network ® (NCCN ® )—a non-profit alliance of leading cancer centers—hosted a Patient Advocacy Summit in Washington, D.C. , today. The annual event brings together leading experts to promote strategies and best practices for improving cancer care. This year's summit focused on practice and policy solutions for sharing accurate, evidence-based health information with patients and caregivers. It featured a keynote address from W. Kimryn Rathmell, MD, PhD, MMHC, Director of the National Cancer Institute (NCI) , along with panel discussions that included Robin Vanderpool , DrPH, Chief of the NCI's Health Communication and Informatics Research Branch . "When people with cancer are empowered to make informed choices about their care, they tend to have better outcomes," said Crystal S. Denlinger , MD, Chief Executive Officer, NCCN , who welcomed attendees at the start of the program. "That means we must provide patients with clear, trustworthy information that meets them where they are. For example, the NCCN Guidelines for Patients offer plain-language explanations of the latest evidence-based recommendations. They feature expert guidance on most cancer types, along with prevention, screening, and supportive care. We share them in multiple languages and formats, including books and webinars." "Every person facing cancer needs and deserves high-quality information to understand their options and guide their decisions. The National Cancer Institute, NCCN, and other organizations represented at the summit contribute to a complex information landscape to meet the needs of people with cancer," said Dr. Rathmell. "Trust in the cancer research enterprise is essential to ensuring that scientific progress includes and reflects the diversity of patient experiences and providing reliable health information is a key aspect of earning and honoring that trust." During a series of Best Practices Presentations for sharing patient-centered health information, NCCN's Senior Director of Patient Information Operations, Dorothy Shead , explained that the NCCN Guidelines for Patients ® are available for free at NCCN.org/patientguidelines or via the NCCN Patient Guides for Cancer App —thanks to funding via the NCCN Foundation ® . Additional presentations came from spokespeople for We Engage 4 Health, HPV Cancers Alliance, Cancer Support Community, and the Frontier & Rural Patient Navigators at the University of Utah Huntsman Cancer Institute. More information can be found in a new resource toolkit at NCCN.org/patient-advocacy-resources . Preventing the spread of misinformation Speakers underscored the need to identify and debunk any myths that can create misunderstanding and a false sense of security. They discussed the importance of working with trusted messengers to counter misinformation. "A key lesson learned from COVID-19 was the importance of having trusted professional and community advocates address misinformation and disinformation," noted Martha Dawson , DNP, RN, FAAN, FACHE , Immediate Past President, National Black Nurses Association . "Diverse researchers, scientists, policymakers, faith-based leaders, and community advocates with similar lived experiences can serve as sources of trusted information. It is important to support and expand cancer education at the community level and engage with people where they are born, live, work, play, worship and transition life." "Misinformation in cancer care can create confusion, delay treatment, and undermine trust between patients and providers. By addressing these challenges head-on, we can empower patients with accurate, accessible information to make informed decisions about their health," agreed Skyler Johnson , MD, Professor, Department of Radiation Oncology, Huntsman Cancer Institute at the University of Utah . "Effective communication is at the heart of quality cancer care. We need to equip clinicians and patients with the tools and strategies to counter misinformation, foster trust, and work together through an increasingly complex healthcare landscape." Clear and consistent messaging to build trust A recurring theme throughout the discussions was the importance of clear and consistent health messaging that is delivered in a way everyone can understand. That means keeping in mind inclusive technology and supportive health literacy levels. Speakers cautioned against using too much medical jargon, instead focusing on language that can resonate. They also noted that it can be hard to retain information right after learning you or a loved one has cancer, so careful repetition can be key. Speakers also reiterated how crucial it is to build trust with each patient through open and honest two-way relationships. "As a survivor and caregiver, I've seen firsthand the impact that clear and culturally-relevant care discussions can have for patients and their families," explained Randi Ervin , Survivor/Advocate, Pancreatic Cancer Action Network (PanCAN) . "Compassionate, empathetic, and relatable communication—delivered at the right time—can make a difficult journey feel a little more manageable for families like mine." Bryce Reeve , PhD, Professor, Population Health Sciences, Duke University School of Medicine, commented: "As a health care system, we have a responsibility to ensure that every individual with cancer has a voice in their care. This is especially important for young children and individuals from marginalized communities whose values, perceptions, and experiences have often been overlooked." "Regardless of our affiliations, whether it be community healthcare, academic medicine, the federal government, or the nonprofit sector, it is critical for us to recognize the richness of collaborating with non-science/healthcare community members to address challenges such as health misinformation and equitable clinical trial participation," concluded Arnethea Sutton, PhD, Interim Assistant Director of Community Outreach and Engagement, VCU Massey Comprehensive Cancer Center . "Not only will these collaborations contribute to trust-building amongst all partners, but the richness of diverse thought and perspectives will contribute to the translation of science and ultimately equitable outcomes for all." Learn more about past NCCN Oncology Policy Summits, and save-the-date for future events, at NCCN.org/summits . Next year's series will include the topics: Primary Care and Oncology Collaboration, Artificial Intelligence, and Unique Needs of Veterans and First Responders. About the National Comprehensive Cancer Network The National Comprehensive Cancer Network ® (NCCN ® ) is a not-for-profit alliance of leading cancer centers devoted to patient care, research, and education. NCCN is dedicated to defining and advancing quality, effective, equitable, and accessible cancer care so all people can live better lives. The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines ® ) provide transparent, evidence-based, expert consensus-driven recommendations for cancer treatment, prevention, and supportive services; they are the recognized standard for clinical direction and policy in cancer management and the most thorough and frequently-updated clinical practice guidelines available in any area of medicine. The NCCN Guidelines for Patients ® provide expert cancer treatment information to inform and empower patients and caregivers, through support from the NCCN Foundation ® . NCCN also advances continuing education, global initiatives, policy, and research collaboration and publication in oncology. Visit NCCN.org for more information. Media Contact: Rachel Darwin 267-622-6624 darwin@nccn.org View original content to download multimedia: https://www.prnewswire.com/news-releases/nccn-hosts-patient-advocacy-summit-on-improving-access-to-accurate-health-information-302325181.html SOURCE National Comprehensive Cancer NetworkINGLEWOOD, Calif. (AP) — For the second straight season, the Philadelphia Eagles are headed to SoFi Stadium with a lengthy winning streak and a team that looks like one of the best in the NFC. The Los Angeles Rams (5-5) couldn't do much to slow them down last season, but they'll try again Sunday night with a young team that hopes to get where the Eagles (8-2) are already standing — atop their division with a six-game winning streak. Javascript is required for you to be able to read premium content. Please enable it in your browser settings.

y7a In conclusion, the intertwining stories of these celebrity families and their interactions with luxury cars have sparked intrigue, admiration, and contemplation among the public. As we follow their journeys through the lenses of social media and entertainment, we are reminded of the diverse paths, values, and experiences that shape our perceptions of success and fulfillment in the contemporary world.

After Thanksgiving, I watched a new documentary that set me at odds with December’s frenzied pace. For me, the month has evolved from a time of calm reflection into a month of haves and wants. National Geographic’s “Tsunami: Race Against Time” chronicles the ravaging impact of the 2004 Indian Ocean eruption on Thailand and numerous other Southeast Asian countries. It hit me hard and gave me the jolt to ask myself how to get off the consumer train. Southeast Asia has my heart; my family and I lived in Asia beginning in the early 2000s. Our children were little then, and we established a set of holiday traditions that meant Christmas in Bangkok with minimal gifts and maximum adventures. The Thais are beautiful people, welcoming and gracious. The Dec. 26, 2004, earthquake and resulting tsunami in the Indian Ocean wrecked countless lives. It killed nearly a quarter of a million people in that region, including thousands of Thais and tourists. The documentary is spellbinding. The viewer becomes a participant in the unbelievable scenery and chaotic devastation the giant waves caused in the early hours of the day after Christmas. Watching the four-part series on a streaming platform created an alarming experience of seeing the water washing away beachgoers, buildings, and even a train. Frequent advertising, however, distracted from and contrasted with the presentation. Ads for mobile phones, fast-food restaurants and shoes horrifyingly broke up the narrative every few minutes: T-Mobile, Chick-fil-A, and DSW in between actual human misery. Relentless phone ads foreshadowed the documentary’s disaster just before smartphones became omnipresent. Ironically, frantic scientists in the Pacific Tsunami Warning Center in Honolulu were tracking the earthquake and tsunami in real time and struggled as they had few options to warn the millions of people who dotted the ocean’s coastlines and were exposed and vulnerable to the massive waves. Today’s ads show an American life that seems superficial, too loud, too brightly lit, and primed for consumption compared with 20 years ago. Toggling between the ads and the documentary left me thinking about how to revise my forecast. I don’t want to be an extreme version of humankind. Too many technology advancements are going somewhere scary where we all require experiences and stuff on demand, catered precisely to our highly refined sense of personal algorithms. I know a lot of good comes from the high-tech advancements, including ways to help warn about natural disasters such as future tsunamis. What is not good is the louder, self-focused lives presently occupied. I will do better in 2025. I will think more about how to spend my time, effort, and money and try to pay back. I don’t want to be that extreme version of humans that play out in those commercials. Do you? Megan Giles Cooney is a columnist for the Traverse City (MI) Record-Eagle, a CNHI newspaper along with The Daily Item. Reach her at megan.cooney1@gmail.com .

In conclusion, the ban on the Police Chief from leaving the country over allegations of actions during the emergency martial law period highlights the challenges and responsibilities faced by law enforcement officials in upholding the rule of law and protecting human rights. It serves as a reminder that the actions of public officials must always be in line with legal and ethical standards, especially in times of crisis. It is imperative that a thorough investigation is conducted to shed light on the truth and ensure accountability for any misconduct. The outcome of this case will have profound implications for the credibility and integrity of law enforcement agencies in South Korea.Residents have been urged to “leave immediately” amid an out of control bushfire in Victoria’s southwest. Victoria Emergency issued the warning just after 2am on Thursday for those in Big Cord, Grampians, Mirranatwa and Jimmy Creek. The alert stated a bushfire at Grampians National Park on Yarram Gap Road is not under control. The fire is crossing Henham Track near the Victoria Valley Road while a private property in the Mirrantwa has been impacted. Grampians Road has been closed from Silverband Road to the southern Victoria Valley Road intersection, while Victoria Valley Road has been closed at the Victoria Point Intersection. Yarram Gap Road has also been closed from Grampians Road to Moyston-Dunkeld Road. Residents have been urged to leave now. “Leaving immediately is the safest option, before conditions become too dangerous,” the alert stated. “Emergency services may not be able to help you if you decide to stay.” People have been encouraged to leave via Victoria Valley Road towards Dunkeld, where a relief centre has been opened at 14 Sterling Place. “If in attendance and require assistance from the Southern Grampians Shire please phone the number provided on site. Victoria Police can also be contacted via the Hamilton Police 24 hour number posted onsite,” the Victoria Emergency alert stated. The alert also reminded people to ensure they take pets, medications, phones and chargers with them. Those unable to leave have been urged to stay inside and close all doors, windows, vents, and turn off cooling systems. “You must take shelter before the fire arrives. The extreme heat is likely to kill you well before the flames reach you,” the alert stated. “Shelter in a room that has two exits, such as a door or window including one directly to the outside. It is important to be able to see outside so you know what is happening with the fire. “If your home catches on fire and the conditions inside become unbearable, you need to get out and go to an area that has already been burnt.” Victoria Emergency recommended sheltering in the middle of a large open area such as a ploughed paddock, football oval or sporting reserve for those unable to get inside. Entering a large body of water, including a dam, lake, river, the ocean or in-ground pool are other options.Houston writer and director premieres short film 'Mildred 4 a Million' inspired by her grandmother

Electric vehicles ( EVs ) aim to transform transportation. However, like any groundbreaking technology, EV batteries have hurdles to overcome before EVs become widely adopted. Some common criticisms of EVs center around their long charging times and shorter driving range compared to gas-powered vehicles. That's where QuantumScape ( QS 2.38% ) comes in. The company is dedicated to engineering batteries that overcome the obstacles current lithium-ion batteries face and make EVs more appealing to consumers. Earlier this year, QuantumScape made headlines with excellent results during an endurance test of its battery. It has also secured funding to extend its runway and recently hit a significant milestone with the shipment of its B-sample cells for further testing. QuantumScape is making progress, but the stock is 96% below its peak price from four years ago and near an all-time low. While its low price may make it seem appealing, there are some things you should know if you're considering scooping up the stock today. It's looking to solve some big EV challenges QuantumScape aims to revolutionize battery technology and address several obstacles that have hindered the widespread adoption of EVs. Its cutting-edge solid-state lithium-metal batteries promise to make important advancements in several key areas : increased energy density, quicker charging times, and superior safety measures when compared to traditional battery systems. The company had established a strategic partnership with Volkswagen . Earlier this year, Volkswagen's battery division, PowerCo, tested QuantumScape's solid-state batteries and reported stellar results, achieving 1,000 charging cycles, with the battery cells showing minimal wear signs. This indicates that an electric vehicle equipped with their technology could potentially cover over 500,000 kilometers without experiencing a noticeable decrease in range. Its battery technology is undergoing rigorous testing Last month, QuantumScape stock surged higher after it announced it was producing and shipping out low volumes of its B-sample cells . The company says this was its most important goal for 2024, and it began shipping these cells to its automotive customers for extensive testing. This testing by automakers will take months to complete. This is part of a three-step process, involving A, B, and C prototype cells to undergo internal and customer testing before the commercial production of its product, QSE-5. Ultimately, the company looks to validate that its technology enables EVs to drive further, charge faster, and operate more safely than those in the market today. Keep an eye on its cash burn QuantumScape's battery technology is coming along, but the company is pre-revenue and continues to burn cash in the meantime. Through the first nine months of this year, QuantumScape has an operating loss of $397 million, up from its operating loss of $354 million last year through the same period. QS Cash from Operations (Quarterly) data by YCharts To help with cash flow, QuantumScape agreed to grant PowerCo the license to mass produce battery cells based on QuantumScape's technology. Under the license, PowerCo can manufacture up to 40 gigawatt-hours (GWh) per year, with the option to double this production to 80 GWh. This would be enough to power roughly 1 million vehicles per year. Is QuantumScape a buy today? QuantumScape's agreement with PowerCo extends QuantumScape's cash runway by 18 months to 2028 , thanks to a $130 million prepayment of royalties from PowerCo. It also allows the company to take a capital-light approach and reach its gigawatt-hour scale faster under its prior agreement. However, QuantumScape continues to burn cash today, and several steps need to happen before its batteries can be manufactured at scale and commercialized. Not only that, but according to the four analysts covering the company, it won't be until 2029 that QuantumScape generates positive net income. In the meantime, its stock price will be driven by its progress with its B-samples and further prototype development. For these reasons, investing in the up-and-coming battery technology company is highly speculative and risky, and most investors are best off watching this one from the sidelines for now.

Heavy travel day starts with brief grounding of all American Airlines flightsAlyssa Nakken, first full-time female coach in MLB history, leaving Giants to join Guardians CLEVELAND (AP) — Alyssa Nakken, the first woman to coach in an MLB game, is leaving the San Francisco Giants to join the Cleveland Guardians. Nakken made history in 2022 when she took over as first-base coach following an ejection. A former college softball star at Sacramento State, Nakken joined the Giants in 2014 and was promoted to a spot on manager Gabe Kapler’s staff in 2020, becoming the majors’ first full-time female coach. Nakken has been hired as an assistant director within player development for the Guardians, who won the AL Central last season under first-year manager Stephen Vogt. Nakken, 34, will work with former Giants coaches Craig Albernaz and Kai Correa. Officer kills pet dog mistaken for a coyote in Massachusetts town. The owner says it was unnecessary An animal control officer shot and killed a pet dog in a Massachusetts town after mistaking it for a coyote in an incident local police are describing as a sad mix-up. Police in Northbridge, Massachusetts, say the shooting happened on Tuesday after police received a call of a report of a coyote in a residential backyard. Police say the animal control officer went into the woods to look for the coyote and found what they thought was the animal in a threatening position and shot it. The incident happened as communities around Massachusetts and the country have dealt with an uptick in interactions between coyotes and people. Kendrick Lamar surprises with new album 'GNX' LOS ANGELES (AP) — Kendrick Lamar gave music listeners an early holiday present with a new album. The Grammy winner released his sixth studio album “GNX” on Friday. The 12-track project is the rapper’s first release since 2022’s “Mr. Morale & The Big Steppers.” Lamar’s new album comes just months after his rap battle with Drake. The rap megastar will headline February's Apple Music Super Bowl Halftime Show in New Orleans. The 37-year-old has experienced massive success since his debut album “good kid, m.A.A.d city” in 2012. Since then, he’s accumulated 17 Grammy wins and became the first non-classical, non-jazz musician to win a Pulitzer Prize. NBA memo to players urges increased vigilance regarding home security following break-ins MIAMI (AP) — The NBA is urging its players to take additional precautions to secure their homes following reports of recent high-profile burglaries of dwellings owned by Milwaukee Bucks forward Bobby Portis and Kansas City Chiefs teammates Patrick Mahomes and Travis Kelce. In a memo sent to team officials, a copy of which was obtained by The Associated Press, the NBA revealed that the FBI has connected some burglaries to “transnational South American Theft Groups” that are “reportedly well-organized, sophisticated rings that incorporate advanced techniques and technologies, including pre-surveillance, drones, and signal jamming devices.” Ancient meets modern as a new subway in Greece showcases archaeological treasures THESSALONIKI, Greece (AP) — Thessaloniki, Greece’s second-largest city, is opening a new subway system, blending ancient archaeological treasures with modern transit technology like driverless trains and platform screen doors. The project, which began in 2003, uncovered over 300,000 artifacts, including a Roman-era thoroughfare and Byzantine relics, many of which are now displayed in its 13 stations. Despite delays caused by preserving these findings, the inaugural line has been completed, with a second line set to open next year. Conor McGregor must pay $250K to woman who says he raped her, civil jury rules LONDON (AP) — A civil jury in Ireland has awarded more than $250,000 to a woman who says she was raped by mixed martial arts fighter Conor McGregor in a Dublin hotel penthouse after a night of heavy partying. The jury on Friday awarded Nikita Hand in her lawsuit that claimed McGregor “brutally raped and battered” her in 2018. The lawsuit says the assault left her heavily bruised and suffering from post-traumatic stress disorder. McGregor testified that he never forced her to do anything and that Hand fabricated her allegations after the two had consensual sex. McGregor says he will appeal the verdict. At least 19 people are sick in Minnesota from ground beef tied to E. coli recall U.S. health officials say at least 19 people in Minnesota have been sickened by E. coli poisoning tied to a national recall of more than 167,000 pounds of potentially tainted ground beef. Detroit-based Wolverine Packing Co. recalled the meat sent to restaurants nationwide. Minnesota state agriculture officials reported multiple illnesses and found that a sample of the product tested positive for E. coli, which can cause life-threatening infections. No illnesses have been reported outside of Minnesota. Symptoms of E. coli poisoning include fever, vomiting, diarrhea and signs of dehydration. Actor Jonathan Majors’ ex-girlfriend drops assault and defamation lawsuit against once-rising star NEW YORK (AP) — Jonathan Majors’ ex-girlfriend has dropped her assault and defamation lawsuit against the once-rising Hollywood star after reaching a settlement. Lawyers for Majors and Grace Jabbari agreed to dismiss the case with prejudice Thursday. Jabbari is a British dancer who had accused Majors of subjecting her to escalating incidents of physical and verbal abuse during their relationship. Representatives for Majors didn’t respond to emails seeking comment Friday. Jabbari’s lawyer said the suit was “favorably settled” and her client is moving on with “her head held high.” Majors was convicted of misdemeanor assault and harassment last December and sentenced to a yearlong counseling program. Hyundai, Kia recall over 208,000 electric vehicles to fix problem that can cause loss of power DETROIT (AP) — Hyundai and Kia are recalling over 208,000 electric vehicles to fix a pesky problem that can cause loss of drive power, increasing the risk of a crash. The recalls cover more than 145,000 Hyundai and Genesis vehicles including the 2022 through 2024 Ioniq 5, the 2023 through 2025 Ioniq 6, GV60 and GV70, and the 2023 and 2024 G80. Also included are nearly 63,000 Kia EV 6 vehicles from 2022 through 2024. The affiliated Korean automakers say in government documents that a transistor in a charging control unit can be damaged and stop charging the 12-volt battery. Dealers will inspect and replace the control unit and a fuse if needed. They also will update software. Christmas TV movies are in their Taylor Swift era, with two Swift-inspired films airing this year Two of the new holiday movies coming to TV this season have a Taylor Swift connection that her fans would have no problem decoding. “Christmas in the Spotlight” debuts Saturday on Lifetime. It stars Jessica Lord as the world’s biggest pop star and Laith Wallschleger, playing a pro football player, who meet and fall in love, not unlike Swift and her boyfriend, Kansas City Chiefs tight end Travis Kelce. On Nov. 30, Hallmark will air “Holiday Touchdown: A Chiefs Love Story.” Instead of a nod to Swift, it’s an ode to family traditions and bonding, like rooting for a sports team. Hallmark’s headquarters is also in Kansas City.In conclusion, the potential signing of the Premier League Golden Boot winner by Barcelona has generated a buzz of anticipation and excitement among fans and pundits alike. The prospect of witnessing his skills and goal-scoring prowess at the Camp Nou is a tantalizing one, as the Catalan giants look to strengthen their squad and mount a serious challenge for silverware in the upcoming season. Stay tuned for further developments as the transfer saga reaches its climax, and brace yourself for the arrival of a top-class winger in the iconic colors of Barça!

While six weeks may seem like a significant amount of time for Beverley to be sidelined, it is important for him to prioritize his long-term health and well-being. Rushing back to action too soon could exacerbate the injury and prolong his recovery process, potentially leading to more serious complications down the road.

Are you helping an elderly parent with some holiday shopping and need to get reimbursed? Have they asked you to pay some bills or e-transfer funds to the grandkids from their accounts? You aren’t alone. While 70 per cent of Canadians age 65+ use online banking , older adults sometimes rely on people close to them to help with banking tasks. Our research, based on a survey of 42 participants, shows that older adults often share their banking passwords with trusted caregivers because banks have not provided a better way to allow caregivers to help. Most caregivers are well meaning, honest and provide a valuable service to society by helping older adults with their banking. This practice, while convenient, puts older adults at risk for financial abuse. It has been estimated that at least 6.8 per cent of older adults have experienced financial abuse globally. The need for better banking It is important to help older adults age in place, meaning providing them with the ability to live independently and comfortably in their own homes as they grow older. Support with banking tasks is a critical component of this. A 2019 survey found that 20 per cent of Canadians bank on behalf of someone else. Banks offer two mechanisms to enable caregivers to bank for older adults: trustee accounts and joint accounts. Trustee accounts are appropriate when older adults lack decision-making capacity. A financial power of attorney gains complete control over the older adult’s accounts. However, this is not suitable for independent older adults who only need occasional support with banking. Joint accounts require adding a caregiver as a legal account holder. This is commonly set up for adult children of older adults. With joint accounts, each person has their own login credentials so the older adult doesn’t have to share their password with the caregiver and the bank can see who makes each transaction. Joint accounts are helpful in the event the older adult passes on — they allow the caregiver to pay bills and funeral expenses without having to jump through legal hoops. However, joint accounts can be problematic because they assume joint ownership of assets , which means a caregiver could misuse these assets . In such cases, there is no protection or recourse for the older adult. Older adults may be unlikely to report such situations if they are dependent on the caregiver for support. In addition, not all older adults have an adult child or other close family member, so joint accounts are sometimes inappropriate. Risks of password sharing Our survey study and interview study both showed that older adults often share their banking passwords with their caregivers so they can pay bills, monitor balances, transfer funds or send e-transfers. Password sharing can be problematic for a host of reasons. First and foremost, it puts the older adult at risk of financial abuse. Password sharing can open the door for caregivers to take extra money for themselves or use the older adult’s accounts to pay their own bills . When an older adult shares their password, a bank can’t tell whether it’s the older adult making transactions or their caregiver. This makes it more difficult for banks to detect fraudulent activity. Password sharing also has privacy issues. Caregivers can see past transactions, and they can see how much money the older adult has in other accounts. Research has also shown that password reuse is common . A shared banking password may inadvertently also give caregivers unintended access to the older adult’s email, online shopping or social media accounts . The Canada Revenue Agency allows people to login to their CRA My Accounts by authorizing through their bank , so password sharing can also give caregivers the ability to redirect an older adult’s tax refunds and benefits. Our research also shows that bank password sharing makes caregivers feel uncomfortable and illegitimate as though they are impersonating the older adult just to help with banking tasks. Proxy accounts could help Banks could support older adults and their caregivers by implementing proxy accounts. These are lightweight delegation accounts that allow someone to officially do banking on behalf of someone else. We conducted an interview study with older adults and caregivers and all 21 participants who tried out our prototype of a proxy bank account were positive, with many of them asking how they can sign up for one. Proxy accounts give caregivers their own login credentials, which means banks and older adults can track what transactions their proxies make. This setup allows older adults to keep their banking passwords private. Proxy accounts place limits on what proxies can see. For example, a caregiver might only have access to a chequing account, but not savings or retirement accounts. Proxy accounts also offer limits on what a proxy can do, such as only paying bills to existing payees or only sending e-transfers up to $200. Proxy accounts enable older adults to get the help they need while protecting their privacy and their financial assets. They provide caregivers with legitimacy and accountability so they don’t have to impersonate an older adult just to help pay some bills. The technology to support proxy accounts is straightforward, but these accounts are not currently offered by banks or credit unions in Canada. If Canada’s banks or credit unions were to provide such accounts, it would make a difference in supporting older adult clients while gaining a competitive advantage.

In conclusion, the current season of the English Premier League has seen a display of exceptional dribbling skills by players like Allan Saint-Maximin and Adama Traore. Their ability to navigate past opponents with finesse and flair has elevated their status as key playmakers in their respective teams. As the season unfolds, football fans can look forward to more moments of brilliance and artistry from these skilled dribblers, who continue to captivate audiences with their talent and creativity.

The Vegas Golden Knights (14-6-2) take on the Colorado Avalanche (12-10-0) Wednesday. Puck drop from Ball Arena is set for 10 p.m. ET (TNT). Let's analyze BetMGM Sportsbook's NHL odds around the Golden Knights vs. Avalanche odds and make our expert NHL picks and predictions . Season series: Golden Knights lead 1-0 The Knights won their third in a row with a 5-4 shootout victory in Philadelphia Monday. C Jack Eichel netted his 8th goal of the season, and C Ivan Barbashev scored his 10th in the victory. Eichel has a point in 9 of 10 games. The Knights were 3-1 on the road trip, only losing the opener. Already without RW Mark Stone , the Knights could be without a couple of their best defensemen with Alex Pietrangelo and Zach Whitecloud questionable with upper-body ailments. The Avs ended a 3-game winning streak by an 8-2 landslide in Tampa Monday. The only player to score was 22-year-old C Ivan Ivan , and much like his name, he likes things in twos as he scored both goals. C Nathan MacKinnon has just 2 points in the last 5 games. Stream the NHL all season on ESPN+ , with your team's out-of-market games, exclusive games, originals and more. Get ESPN+ now! Golden Knights at Avalanche odds Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NHL odds. Lines last updated at 5:20 p.m. ET. Golden Knights at Avalanche projected goalies Adin Hill (9-4-1, 2.99 GAA, .887 SV%, 1 SO) vs. Alexandar Georgiev (6-5-0, 3.49 GAA, .871 SV%) Hill has been solid, but unspectacular this season. He has allowed exactly 2 goals in 4 straight starts, and he's 3-1-0 in those. He allowed 2 goals on just 17 shots against the Montreal Canadiens Saturday in a 6-2 win. He was 2-0-0 with a 1.48 GAA and .954 SV% against the Avs last season. Georgiev was OK in 2 wins since coming off IR last week. He stopped 28 of 29 he saw against Washington Thursday and 27 of 31 he saw against Florida Saturday. He was thrust into relief duty Monday, allowing 3 goals on 17 shots in the 8-2 laugher. He was 1-1-1 with a 3.64 GAA and .876 SV% in 3 starts against VGK a season ago. Golden Knights at Avalanche picks and predictions Prediction Avalanche 3, Golden Knights 2 Moneyline I really want to lean toward Vegas (+140) here, but the banged-up defensemen moves the needle to Colorado (-165). The Avs' ML is out of my price range for the lackluster goaltending they've received all season. One player that is not banged up for Vegas is D Noah Hanifin . He had 3 shots on goal in the last game and has a 3-game point streak. Take NOAH HANIFIN OVER 0.5 POINTS (+160) for a sizeable payout. Puck line/Against the spread I like the GOLDEN KNIGHTS +1.5 (- 165 ) more than I do the Avs ML at the same price. The Avs have scored just 3 empty-net goals this season, and with my feeling that Vegas could take this one outright, this seems like a good wager. Over/Under We're going UNDER 6.5 (+ 100 ) because it's going to have to be an Under game for Colorado to stay in it. Vegas' defensemen are huge oak trees, and the Avs have scored more than 3 against VGK once in the last 10 meetings. TAKE UNDER 6.5 (+ 100 ). Play our free daily Pick’em Challenge and win! Play now ! For more sports betting picks and tips , check out SportsbookWire.com and BetFTW . Follow Ryan Dodson on Twitter/X . Follow SportsbookWire on Twitter/X and like us on Facebook . More NHL Picks and Predictions! Toronto Maple Leafs at Florida Panthers odds, picks and predictions Washington Capitals at Tampa Bay Lightning odds, picks and predictions Vancouver Canucks at Boston Bruins odds, picks and predictionsg#7 。

After a bit of a wait to get to the NHL with the Pittsburgh Penguins, Vasily Ponomarev’s first tryout is over. After three games in the NHL lineup, Ponomarev, 22, will take those lessons learned after a few rocky outings back the Wilkes-Barre/Scranton Penguins of the AHL. The Penguins sent Ponomarev back to WBS Saturday to make room for Kevin Hayes , whom the club activated later Saturday afternoon. Ponomarev didn’t record a point in his three games. Hayes, 32, has been on IR. In 14 games, the forward has four points (1-3-4), and coach Mike Sullivan officially termed him a game-time decision. Valtteri Puustinen remains on the NHL roster, so if Hayes is unable, Puustinen would get the 12th sweater, unless the team dresses seven defensemen. The Penguins face the Utah Hockey Club Saturday at PPG Paints Arena. Faceoff is set for 7:08 p.m. This article first appeared on Pittsburgh Hockey Now and was syndicated with permission.

Nebraska football is going bowling: Where could the Huskers end up?Former UFC middleweight champion Israel Adesanya has shed light on his retirement plans, acknowledging that his illustrious fighting career may soon be coming to an end. ‘The Last Stylebender,’ now 35, last competed at UFC 305 in August, where he suffered a fourth-round submission loss to South African middleweight champion Dricus du Plessis. The bout marked Adesanya’s first since losing his title in a shock decision defeat to Sean Strickland a year earlier. Speaking on the FLAGRANT Podcast, Adesanya reflected on his achievements in the sport and hinted at a possible timeline for his retirement. “I’ve said this already, with what I’ve already done in this game, a lot of people don’t even get to the belt, get to the UFC,” he stated. “I’ve done it twice. Still the only two-time UFC middleweight champion.” Related News Adesanya to headline UFC event in Saudi Usman warns young prospect who called out Adesanya UFC: Adesanya ‘insulted’ by Magomedov challenge Adesanya admitted he remains unbooked for a return to the Octagon but has been linked to a potential clash with Nassourdine Imavov at UFC Saudi Arabia next year. While he still has ambitions to achieve more in the sport, he is also realistic about the toll it takes. “You’ve got to break up with fighting before fighting breaks up with you,” Adesanya explained. “When will I? I don’t know... I’m 35 now. I know I’m over the halfway point and I’m definitely a few years away, maybe three years away. But who knows? I know I don’t want to be fighting at 40.” Despite the uncertainty, Adesanya remains proud of his journey, having captured the middleweight belt twice—an accomplishment that cements his legacy as one of the sport’s greats. “If what I’ve already done won’t make me happy, what will? I’m happy but I’m not content,” he said, hinting at a few more goals he wishes to achieve before stepping away from the cage.

2024: Best celestial displays visible in PHCEC's Generation of Environmental Leaders Program Now Open to North American Youth!Niagara County implements new eye identification technology in patrol vehicles

TEXAS, USA — The Texas Supreme Court on Friday overturned a lower court ruling that would have made state Attorney General Ken Paxton testify in a whistleblower lawsuit at the heart of impeachment charges brought against him in 2023 . The court on Friday said Paxton’s office does not dispute any issue in the lawsuit by four former Paxton employees and agreed to any judgment in the case. “In a major win for the State of Texas, the state Supreme Court has sided with Attorney General Paxton against former OAG employees whose effort to prolong costly, politically-motivated litigation against the agency has wasted public resources for years," a statement from Paxton's office said. An attorney for one of the plaintiffs declined immediate comment, and a second attorney did not immediately return a phone call for comment. The former employees allege they were improperly fired or forced out for bringing to the FBI allegations that Paxton was misusing his office to protect a friend and campaign donor, who in turn, they said, was helping the attorney general to conceal an extramarital affair. The Supreme Court ruling noted that the Texas governor and Legislature have expressed a desire to hear testimony from the witnesses prior to agreeing to appropriate funds to settle the lawsuit. The court said forcing Paxton, First Assistant Attorney General Brent Webster, Chief of Staff Lesley French Henneke and senior advisor Michelle Smith to testify earlier could improperly be used for legislative purposes in deciding any appropriation. Under the preliminary deal , Paxton agreed to apologize to the former employees for calling them “rogue” employees, settle the case for $3.3 million and ask the state to pay for it, prompting the state House to reject the request and begin its own investigation, leading to the vote to impeach him. Paxton was ultimately acquitted after a Senate trial. The Supreme Court termed its ruling conditional upon the lower trial court complying with the decision, while saying it is “confident the trial court will comply” with the order.Unretired two-time Pro Bowl LB Shaquil Barrett signs to resume career with Tampa Bay Buccaneers

Stanley has been busier than ever this December and we’re only one week in. In case you missed it, Stanley released a whole slew of new tumblers, including a limited-edition Christmas Scarlet Tinsel tumbler, the long-awaited leakproof ProTour Flip Straw Tumbler with Leakproof Lid , and Leo Messi GOAT collection . Normally, it takes a little while for new Stanley releases to make it to Amazon, but you can already buy the ProTour Flip Straw Tumbler in four different sizes (14 oz., 20 oz., 30 oz., and 40 oz.) in a variety of different colors. These tumblers range in price from $20 to $45, depending on which size you buy. The real beauty of Quencher ProTour Flip Straw Tumblers is the leakproof ProTour Flip Straw lid. The new lid design allows you to “flip up the built-in straw to sip, then snap it shut when you’re done,” so the tumbler is finally leakproof. Stanley has also taken a step back from its traditional logo design with a vertical logo placement. The tumblers also have a two-tone lid and all the other features of Stanley’s classic Quenchers. Stanley Leakproof Tumbler: Where to find it on Amazon Since this product is brand new and was highly requested, a number of colors are already out of stock on Amazon. Only the 30 oz. and 40 oz. are available and in stock in every color on Amazon right now. Stanley Quencher ProTour Flip Straw Tumbler with Leakproof Lid 14 oz – For $20 – Only available in Black Fade Stanley Quencher ProTour Flip Straw Tumbler with Leakproof Lid 20 oz – For $30 – Available in Azure Fade and Vivid Violet Fade Stanley Quencher ProTour Flip Straw Tumbler with Leakproof Lid 30 oz – For $35 – Available Azure Fade, Black Fade, Black Solid, Cream Solid, Frost Fade, Frost Solid, Rose Quartz Fade, Rose Quartz Solid, and Vivid Violet Fade Stanley Quencher ProTour Flip Straw Tumbler with Leakproof Lid 40 oz – For $45 – Available Azure Fade, Black Fade, Black Solid, Cream Solid, Frost Fade, Frost Solid, Rose Quartz Fade, Rose Quartz Solid, and Vivid Violet Fade The Best Gift Guides of 2024 16 gift ideas for ‘Nightmare Before Christmas’ fans 20 travel gifts for the jetsetter in your life 8 Black Friday video game deals to add to your wish list Where to find these 11 Christmas toys at the top of everyone’s wish list for 2024 before they sell out 30 skincare and makeup gifts you need to add to your Christmas wish list Our journalism needs your support. Please subscribe today to NJ.com . Dawn Magyar can be reached at dmagyar@njadvancemedia.com . Have a tip? Tell us at nj.com/tips/ .Bovista set out in search of their first Primeira Liga home win when they go head to head with SC Farense in round 13 of the Portuguese Primeira Liga on Sunday. As for the Leoes de Faro , they journey to the Estadio do Bessa looking to end their run of four back-to-back defeats against the home side and make it three wins on the spin for the first time since September 2023. © Imago Boavista were denied consecutive Primeira Liga away wins for the first time since September 2023 as they played out a goalless draw with Nacional at the Estadio da Madeira last Saturday. A total of 31 shots were fired in the game, but with both sides failing to tuck away their chance, neither goalkeeper would end up picking ball out of the back of the net, with a draw being a fair result upon reflection. Before that, Boavista snapped their run of nine consecutive matches without a win in all competitions on November 2, when they edged out Gil Vicente 2-1 at the Estadio Cidade de Barcelos, one week before crashing down to earth in a 2-0 home defeat at the hands of Rio Ave. While Cristiano Bacci 's men have been decent on the road, where they have picked up one win and two draws from their last three games, they now return home, where they are the only side yet to taste victory this season, picking up just one point from their five matches so far. Boavista have lost six of their 12 Primeira Liga matches so far while claiming two wins and four draws to collect 10 points and sit 13th in the standings , level on points with Gil Vicente and newcomers AVS. © Imago On the other hand, Farense picked up three huge points on their push from the bottom end of the league table as they picked up a 1-0 victory over Estrela Amadora last weekend. Spanish forward Dario Poveda continued his fine form in front of goal as he netted the only goal of the game midway through the first half to condemn Estrela to their seventh league defeat of the season. This followed a 2-1 victory over Arouca at the Estadio Municipal de Arouca on November 23, when Poveda and Elves Balde found the back of the net to send the Farense through to the fifth round of the Taca de Portugal. Having finished 10th in the Primeira Liga table last season, Toze Marreco 's men have picked up eight points from their 12 Primeira Liga matches so far to sit bottom but one in the table, only above last-placed Arouca on goal difference. Farense will be backing themselves to make it three wins on the trot for the first time since returning to the top flight in May 2023 as they take on an opposing side who have lost each of their last four games, conceding nine goals and scoring just twice since November 2020. © Imago Having missed the game against Nacional through suspension, Sebastian Perez should return the fold, teaming up with Joel Silva , Ilija Vukotic and Salvador Agra at the centre of the park. Af the defensive end of the pitch, we should see a back four of Pedro Gomes , Rodrigo Abascal , Filipe Ferreira and Bruno Onyemaechi , shielding Cesar Dutra between the sticks. On the injury front, Os Axadrezados will take to the pitch without the duo of Morales Pires and goalkeeper Joao Goncalves , who have been ruled out through knee problems. As for Farense, Marreco will be unable to name veteran forward Tomane , who has missed each of the last eight matches since picking up an injury back in September. He is joined on the club's injury table by 25-year-old midfielder Filipe Soares , who is set to sit out his eighth straight game since coming off injured against AVS on September 30. Boavista possible starting lineup: Cesar; Gomes, Abascal, Ferreira, Onyemaechi; J Silva, Vukotic, Perez, Agra; Bozenik, Reisinho SC Farense possible starting lineup: Velho; Africo, Falcao, Moreno, Pastor; Neto, Menino, Victor; Matias, Poveda, Balde Looking at previous meetings between Bovista and Farense, we anticipate a thrilling matchup at the Estadio do Bessa as both sides look to continue their surge into the top half of the table. Boavista have struggled to impose themselves at home but we are tipping them to come away with all three points here. For data analysis of the most likely results, scorelines and more for this match please click here .

NESG Inducts Second Cohort Of Non-Resident Fellows To Champion Evidence-Based PolicymakingGhanaian activist Oliver Barker-Vormawor, a prominent figure in the Democracy Hub, has expressed strong dissatisfaction with the Electoral Commission’s handling of the recent election disputes, accusing the body of undermining judicial processes. Speaking on JoyNews’ NewsFile program, Barker-Vormawor condemned the Supreme Court’s judgment as a “Solomonic judgment,” suggesting that it lacked the clarity and maturity that Ghanaians have been waiting for in order to uphold the rule of law. The case in question involved the Electoral Commission’s (EC) refusal to collate results from four disputed constituencies. The Supreme Court had been approached through a mandamus application, a legal procedure used to compel an entity to perform a duty it is legally obligated to carry out. In this instance, the EC was required to show it had either failed or refused to collate the votes after a reasonable demand had been made, but Barker-Vormawor argues the commission did not make its refusal clear. “The EC never said it was refusing to collate the results, yet it failed to oppose the mandamus,” he noted. “If there’s no refusal or failure from the EC, then there is no legal basis for the mandamus to apply.” Barker-Vormawor went further to criticize the EC’s actions following the High Court’s ruling. Despite a pending application to stay the court’s decision, the Electoral Commission proceeded to re-collate the results in the disputed constituencies, which he described as an unlawful rush. “This is a blatant disregard for the law. The EC went ahead and collated the results, violating the judicial process,” he said. He stressed that such actions demonstrated a concerning trend of the Electoral Commission undermining the judiciary. “When there’s a pending application to stay a court decision, you can’t take actions that disregard the court’s authority,” Barker-Vormawor emphasized. “The EC’s actions in filing an affidavit and then going ahead to gazette the results undermine the very foundation of our democratic processes.” Barker-Vormawor’s comments reflect a growing frustration among civil society groups over the perceived impunity with which state institutions, including the Electoral Commission, operate in Ghana. His remarks highlight the critical need for greater accountability and transparency in electoral processes, especially when judicial decisions are at stake.Costco Will Continue to Gain Market Share, Analyst Says. Plus American Airlines, Sphere, and More Stocks.

Under fire from the all-powerful ICC board after Friday’s virtual meeting failed to achieve consensus over the hosting of the upcoming Champions Trophy , the Pakistan Cricket Board ( PCB ) has reportedly agreed to a hybrid hosting model of the tournament, scheduled to run between February and March next year. According to multiple sources, PCB chairman Mohsin Naqvi, who is currently in the UAE, lobbying for Pakistan’s cause, has put forward a list of conditions, in a bid to help Pakistan retain the hosting rights of the marque tournament. The current predicament around the tournament arose after India remained unwilling to travel to Pakistan for security reasons, and the PCB refused to budge on BCCI’s requests for a hybrid model . Advertisement To end the impasse that has already derailed the ICC’s plans of announcing the schedule 100 days ahead of the tournament, the global body on Friday called for an emergency meeting attended by 12 full ICC members, three associate members, and the ICC Chair but that also failed to cut any ice. Following the meeting, it has been learnt that the ICC communicated to the PCB on accepting the hybrid model as the only viable solution or be prepared to be ousted from the event. Amidst all these, PCB chairman Mohsin Naqvi met Emirates Cricket Board head Mubashir Usmani in Dubai signalling his agreement to the hybrid model . According to a PCB statement regarding the meeting, Naqvi told Usmani that Pakistan was ready to host the Champions Trophy and all the preparations were on schedule. Usmani is also the chairman of the ICC’s associate members’ committee. Naqvi also said that the situation in Pakistan was stable and all teams taking part in the mega-event would be provided state level security. He said the construction work at the stadiums which will host the tournament was also on schedule and the people of Pakistan were looking forward to watching the best teams and players play in the country. Meanwhile, it has been learnt that the PCB ’s acceptance to the hybrid model comes with a set of riders: All matches involving India, including group stages, semi-finals, and the final (if they qualify), will be played in Dubai due to India’s refusal to send its team to Pakistan. If India fails to progress beyond the group stages, Pakistan has secured the right to host the semi-finals and final in Lahore. And finally, if India gets hosting rights of future ICC tournaments, Pakistan’s matches will be played at neutral venues. Bilateral cricket between the two countries have been affected due to frosty political relations. The two arch-rivals last played a bilateral series in 2012-13 in India, comprising white-ball matches. After that, India and Pakistan have primarily faced each other in ICC tournaments and Asia Cups. Last year, when Pakistan were granted the hosting rights of the Asia Cup, India refused to travel to the country, and eventually played their matches in Sri Lanka, including the final, under a hybrid model . Pakistan, however, travelled to India during the 2023 ICC 50-over World Cup. Advertisement

George Mason defeats Ferrum 100-55None

NoneAdvisors Asset Management Inc. decreased its position in shares of Virtu Financial, Inc. ( NASDAQ:VIRT – Free Report ) by 45.9% during the third quarter, according to its most recent filing with the SEC. The firm owned 6,016 shares of the financial services provider’s stock after selling 5,106 shares during the period. Advisors Asset Management Inc.’s holdings in Virtu Financial were worth $183,000 at the end of the most recent quarter. Several other institutional investors have also recently made changes to their positions in VIRT. USA Financial Formulas purchased a new stake in Virtu Financial in the third quarter worth $33,000. International Assets Investment Management LLC purchased a new position in Virtu Financial during the 2nd quarter valued at about $39,000. Abich Financial Wealth Management LLC lifted its position in Virtu Financial by 55.3% during the 1st quarter. Abich Financial Wealth Management LLC now owns 2,193 shares of the financial services provider’s stock valued at $45,000 after acquiring an additional 781 shares during the period. Innealta Capital LLC bought a new stake in Virtu Financial during the second quarter worth about $46,000. Finally, First Horizon Advisors Inc. grew its holdings in Virtu Financial by 21.0% in the second quarter. First Horizon Advisors Inc. now owns 2,143 shares of the financial services provider’s stock worth $48,000 after purchasing an additional 372 shares during the period. Institutional investors own 45.78% of the company’s stock. Virtu Financial Stock Down 0.1 % VIRT stock opened at $37.31 on Friday. The company has a market cap of $5.77 billion, a price-to-earnings ratio of 18.76, a P/E/G ratio of 0.58 and a beta of 0.38. The company has a debt-to-equity ratio of 1.23, a quick ratio of 0.47 and a current ratio of 0.47. The business’s 50-day moving average is $33.10 and its two-hundred day moving average is $28.64. Virtu Financial, Inc. has a fifty-two week low of $16.02 and a fifty-two week high of $38.45. Virtu Financial Dividend Announcement The firm also recently declared a quarterly dividend, which will be paid on Sunday, December 15th. Stockholders of record on Sunday, December 1st will be paid a dividend of $0.24 per share. This represents a $0.96 annualized dividend and a dividend yield of 2.57%. The ex-dividend date is Friday, November 29th. Virtu Financial’s dividend payout ratio is presently 48.24%. Analysts Set New Price Targets Several research firms have recently issued reports on VIRT. Piper Sandler reiterated an “overweight” rating and set a $35.00 target price on shares of Virtu Financial in a report on Thursday, October 24th. The Goldman Sachs Group lifted their price objective on Virtu Financial from $26.00 to $29.00 and gave the company a “neutral” rating in a research note on Monday, September 30th. Citigroup increased their target price on Virtu Financial from $32.00 to $37.00 and gave the stock a “buy” rating in a research note on Wednesday, October 9th. Bank of America lowered their price target on Virtu Financial from $37.00 to $35.00 and set a “buy” rating for the company in a research report on Thursday, October 3rd. Finally, Morgan Stanley increased their price objective on shares of Virtu Financial from $23.00 to $25.00 and gave the company an “equal weight” rating in a research report on Thursday, October 17th. Five investment analysts have rated the stock with a hold rating and three have assigned a buy rating to the stock. According to MarketBeat, the company presently has an average rating of “Hold” and an average target price of $29.50. Get Our Latest Stock Report on Virtu Financial Virtu Financial Profile ( Free Report ) Virtu Financial, Inc operates as a financial services company in the United States, Asia Pacific, Canada, EMEA, Ireland, and internationally. The company operates through two segments, Market Making and Execution Services. Its product includes offerings in execution, liquidity sourcing, analytics and broker-neutral, capital markets, and multi-dealer platforms in workflow technology. Read More Five stocks we like better than Virtu Financial 3 Best Fintech Stocks for a Portfolio Boost The Latest 13F Filings Are In: See Where Big Money Is Flowing Dividend Screener: How to Evaluate Dividend Stocks Before Buying 3 Penny Stocks Ready to Break Out in 2025 Stock Analyst Ratings and Canadian Analyst Ratings FMC, Mosaic, Nutrien: Top Agricultural Stocks With Big Potential Want to see what other hedge funds are holding VIRT? Visit HoldingsChannel.com to get the latest 13F filings and insider trades for Virtu Financial, Inc. ( NASDAQ:VIRT – Free Report ). Receive News & Ratings for Virtu Financial Daily - Enter your email address below to receive a concise daily summary of the latest news and analysts' ratings for Virtu Financial and related companies with MarketBeat.com's FREE daily email newsletter .

Jamiya Neal scores 21, No. 21 Creighton beats Notre Dame 80-76

TAMPA, Fla. (AP) — Two-time Pro Bowl linebacker Shaquil Barrett is rejoining the Tampa Bay Buccaneers. The Bucs signed the two-time Super Bowl champion on Saturday, while also announcing safety Jordan Whitehead was activated from injured reserve ahead of Sunday’s home game against the Carolina Panthers. Barrett spent five seasons with Tampa Bay from 2019 to 2023. He led the NFL with a franchise-record 19 1-2 sacks in his first year with the Bucs, then helped the team win its second Super Bowl title the following season. In all, Barrett started 70 games with Tampa Bay, amassing 45 sacks, 15 forced fumbles, two fumble recoveries and three interceptions. He was released last winter in a salary cap move, signed a one-year contract with the Miami Dolphins in free agency, then abruptly announced his retirement on social media before the start of training camp in July. Barrett, who also won a Super Bowl during a four-season stint with the Denver Broncos, decided to unretire last month. He signed with the Bucs after clearing waivers earlier in the week. Whitehead has missed the past four games with a pectoral injury. His return comes of the heels of the Bucs placing safety Christian Izien on IR with a pectoral injury. On Saturday, the Bucs also activated rookie wide receiver Kameron Johnson from IR and elevated punter Jack Browning to the active roster from the practice squad. NFL: https://apnews.com/hub/nfl

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RE Royalties Announces 2024 Annual General Meeting and Update on Meeting Materials

0×7 Qatar tribune As the Ukraine war, launched by the imperialist invasion by Russian despot Vladimir Putin, passed its 1,000-day mark this month, President Volodymyr Zelenskyy’s troops are newly empowered by the Biden administration to use long-range ATACMS missiles to attack targets in Russia, which they did. And Moscow responded by launching its own new mid-range ballistic missile. Biden is also sending antipersonnel mines to Ukraine, marking a couple significant shifts in strategy in his waning weeks at the helm. What everyone knows is that this late flurry of aid for Kyiv’s defenses may soon change. Donald Trump, with his dangerous America First isolationism, wants out of foreign wars and could leave Ukraine to be mauled and consumed by the Russian bear. He’s said that he intends to end the war “in one day,” which seems to include the idea of significant and unacceptable concessions to Russia and Putin, a strongman whose style Trump has often seemed to admire. Of course, this terrible war should not be prolonged. Even Zelenskyy expressed some optimism that Trump might be able to help end the war sooner, to some extent due to his existing credibility in the Kremlin. There’s a world here where the clarity of Trump’s non-commitment to both Ukraine and the global Western security apparatus and alliances like NATO at least pushes European allies to step up and help broker an end to the conflict that does not constitute a Russian victory. This, however, is only possible if Russia comes to feel that this victory is not possible, or at least comes at too extravagant a cost. That means that Ukraine needs to continue to have the tools not just to defend itself but to strike back, as it has begun doing with the long-range missiles. For its part, Russia has suffered estimated military casualties, including killed and wounded, in excess of 700,000, destroyed its military readiness, is in the midst of uncontrolled inflation and seems destined to at best have an incredibly Pyrrhic victory. Now, it will suffer heavier casualties and infrastructural damage on its own soil from Ukraine’s latest weapons. This doesn’t mean that Ukraine has the upper hand, per se, but it does mean that this is a grinding stalemate that no one really wants to continue. Russia has been increasingly desperate for an edge, now allowing thousands of North Korean troops to join the fray, committed to saving face to protect the aspirations and public image of its despotic leader. But the tides can turn quickly if Ukraine’s means to defend itself begin drying up. So let the Biden administration shore that up for now, and we hope that Trump’s lean towards a Russia-favoring resolution is tempered in the months until he takes office. History and common sense point to a series of escalating consequences if an aggressive and expansionist Russia is allowed to win this war outright in the ways it had initially set out to do — seizing large swaths of territory and rewiring the social and political fabric of the land. Putin will not be appeased, or satisfied with this meal at Ukraine’s expense. He’ll always want more, which is why he must be stopped. Copy 24/11/2024 10Vice Admiral Emmanuel Ikechukwu Ogalla, the Chief of Naval Staff (CNS), has spearheaded a relentless crusade against oil thieves, revolutionizing Nigeria’s maritime security landscape. Since assuming office in June 2023, Admiral Ogalla has leveraged cutting-edge technology, strategic partnerships, and innovative tactics to combat maritime crimes, protect Nigeria’s economic interests, and ensure regional stability. The dynamic and seasoned navigator has embarked upon various instant reforms aimed at not just repositioning the Nigerian Navy but re-writing the narratives, especially with consolidation on the deployment of technology which will be aimed at safeguarding Nigeria’s maritime interests, promoting economic growth, and enhancing regional stability. The transformative blueprint was encapsulated in an ambitious, Nigeria’s Maritime Security and Blue Economy Comprehensive Strategy Agenda; namely, the Total Spectrum Maritime Strategy (TSMS), which is intended to tackle maritime crimes and promote economic growth, and involves the designation of Special Courts for Maritime Crimes, Advocacy Campaigns to enlist community support, and Socioeconomic Crime Prevention Strategies. Also, the TSMS will enhance naval capabilities through fleet renewal, operational readiness, and physical and social infrastructural development, with a premium on human capital development through personnel welfare and motivation, manpower training, and youth and sports development. This aims at maintaining and equipping a professionally competent and ethical naval force, capable of leveraging on all the elements of national powers to effectively defend Nigeria’s maritime area against all forms of threat to deliver the imperatives of national security. To accomplish the agenda, Ogalla engaged strategic stakeholders and other security agencies in a robust confidence-building, partnership and interagency relationship dialogue, drumming the necessity for shaping the security outcomes within Nigeria’s maritime domain and the littorals, including land-based engagements in fulfilment of national interest. This has led to synergy and intelligence sharing amongst various agencies such as NIMASA, NPA, NDLEA, NOSDRA, and NEMA, as well as many foreign bilateral meetings and talks with the American Chief of Naval Service, Operation (CNO), and also enhanced trust, confidence building, synergy and operational successes. The re-equipping of the Naval Shipyard Limited to construct and fabricate small boats, big vessels and other facilities of the Navy, has eliminated capital flight and encouraged the training and development of skilled manpower not just within the Navy but as a means of livelihood afterwards. To have firsthand knowledge of his officers and men, the CNS conducts frequent inspection and supervisory tours of the various Naval ships as part of his avowed commitment to the welfare of the personnel and also to have personal knowledge of their war readiness. The visit has been adjudged to greatly increase the morale of the officers and men, as well as a forum for a one-on-one with the CNS. An efficient and effective strategically pragmatic leader, the CNS deploys both men and materials in the most suitable manner such as to ensure economic utilization. The novel and innovative deployment of technology in combating oil thieves has led to landmark breakthroughs including, the deployment of drones and satellite images. For instance, the intense operation of Operation DELTA SANITY recorded the seizure of 95 wooden boats, the deactivation of 119 storage tank refining ovens, and the deactivation of 447 dugout pits. Other achievements include the deactivation of 120 illegal refining sites and the seizure of 13 fibre boats, the seizure of 9 vehicles and the arrest of 14 vessels and 74 criminal suspects, with the arrest of various vessels including; MT KALI, MT HABOUR SPIRIT, MT SAISNIL, MV TOKITO, MT VINILLARIS, and MT SWEET MIRI. These operations have also effective implications for climate change as they mitigate hazardous air pollution as well as curb sooth. The CNS’s deliberate human capacity development has led to a highly improved professional and well-motivated workforce, that is ethical and with the required competencies to defend the Country’s maritime space against threats of any kind. The Total Spectrum Strategy has led to the Zero Piracy Rating Status of Nigeria by the International Maritime Bureau. The Nigeria Navy through the Maritime Domain Awareness Capacity, has both ensured the compliance of its personnel to civility and also activated deterrent measures to curb negligence and unprofessional conduct of personnel as well as provide all year-round situation awareness of Nigeria’s maritime domain extending to the limits of the Exclusive Economic Zone. Through the use of its Maritime Domain Awareness Facilities, Drones and other technological tools, the Navy has enhanced early detection and swift response to incidences within the maritime environment. Instead of using responders which has proved to be costly both in terms of the responders’ psychology and otherwise, the introduction and integration of drones and AI, by the CNS has achieved tremendous benefits, in areas of surveillance, monitoring and rapid response. Presently, the deployment of technology has assisted in attaining real-time aerial surveillance. Drones equipped with high-resolution cameras and sensors can provide continuous aerial surveillance of pipelines, oil facilities, and surrounding areas, capturing real-time data and visual feeds. Drones can capture detailed images and videos, allowing for the identification of unauthorized activities, potential threats, and illegal taps on pipelines, all of these enhance rapid response. Also, Drones can be swiftly deployed to areas of interest, significantly reducing response times and allowing for immediate assessment of potential theft activities. In remote areas in particular, drones can access hard-to-reach or dangerous areas, providing critical information without exposing responders to potential risks. In the area of criminal detection, prevention and deterrence, with detection being the key reason for the deployment of the technology, early detection and deterrence can be easily and promptly achieved. Early detection, advanced sensors and AI algorithms are now effectively and efficiently used to detect anomalies such as leaks, illegal taps, and unauthorized movements along pipelines thereby preventing wastages and the dangers of scooping and its potential risk. Thermal imaging by drones equipped with thermal cameras is also used to identify heat signatures from illegal activities or equipment tampering, even in low visibility conditions such as nighttime or dense vegetation, this has become a potent tool for deterrence, while the physical visible presence of drones also acts as a deterrent to potential thieves, reducing the likelihood of thefts. While in flight, drones programmed to send automated alerts can automatically alert security personnel and local authorities upon detecting suspicious activities, enabling rapid intervention. It is necessary to note that the innovative mandatory deployment of the technology has led to an unprecedented high level of safety for all, ensuring personnel safety and minimizing the need for personnel to enter hazardous areas, significantly reducing the risk of injury or exposure to toxic substances and dangerous situations including armed attacks by oil thieves. Instead Naval personnel can now monitor and respond to incidents from a safe distance, enhancing overall safety and minimizing direct human involvement. All these leads also to overall cost efficiency, the strengthening of the operational capacity of the Navy and the enhancement of its capability to keep personnel abreast of global trends relating to evolving technological advancements in the maritime industry, as well as maintain a competitive edge during operations. Aside, the use of AI has greatly improved the Nigerian Navy’s decision-making processes, such as predicting the most fuel-efficient way to operate a vessel and has also affected the ship’s navigation system, radar operations or threat-detection systems to help operators process information faster. Part of the achievements of the automatic mode is that the CMS can detect a target and identify, classify and prioritize targets before deploying weapons, although people are involved in decisions about when and how to use weapons. Accordingly, harnessing AI and other technologies has helped the Nigerian Navy more effectively respond to a range of maritime threats such as illegal, unreported and unregulated fishing (IUU); drug smuggling; and piracy, eliminating the loss in revenue suffered annually by Nigeria of about $70 million to IUU fishing perpetrated by a host of foreign fleets, mostly Chinese. Aside from the use of drones and other technological tools, the use of the surveillance facility of the Nigerian Navy known as the FALCON Eye system for the security of the Nigerian Maritime space has also engendered economic prosperity. With the C4i system and the FALCON eye which are platforms that massively complement each other, there is effective intra-agency communication synergy and improved security of the maritime space devoid of security challenges, thereby boosting the courage of both local and foreign investors in the sector. The effective synchronization of the NIMASA C4i and the FALCON Eye of the Nigerian Navy has added to the strides of the FG in reaping the benefits of the blue economy. It is instructive to note that the FALCON eye system of the Nigerian Navy is a state-of-the-art surveillance facility that incorporates various sensors located along the nation’s enormous coastline, such as Radars, long-range Electro Optic Systems with thermal or night vision capability, Automatic Identification System receivers, Weather Stations and marine Very High-Frequency Radios for communication. The integration of these sensors into the Falcon Eye system generates a real-time situational awareness of the activities of vessels in the Nigerian maritime domain and some selected parts in the Gulf of Guinea. The device consists of over-the-horizon radars with a range of 200 miles, long-range electro-optical systems with a range of 30 miles, and automatic identification system (AIS) receivers. These are linked to three regional control centres and a network operations centre to provide real-time situational awareness of the country’s waters. As part of another landmark breakthrough, the CNS has also inaugurated an overarching control facility at Naval Headquarters in Abuja. The Command-and-Control Centre is filled with television screens on one wall, directly faced by at least a dozen individual workstations for monitoring the sensors. The Command-and-Control Centre is to enable the Nigerian Navy to generate a comprehensive intelligence picture of activities within the maritime environment. This will be further analyzed in appropriate cases, dispatching a Nigerian Navy ship for interdiction, investigation, and/or subsequent arrest of erring vessels. Falcon Eye had already facilitated the seizure of hundreds of tankers carrying stolen oil valued at USD10 billion and 1990 vessels engaged in illegal fishing, as well as 100 pirates and 5000 suspected smugglers. The CNS has achieved numerous exploits in the war against oil thieves. His deployment of technology to keep international thieves away from our territorial waters stands as a clear and eloquent testimony of his relentless effort to bring to an end the activities of oil thieves and criminal elements along the maritime corridor. The effective and collaborative utilization of the FALCON Eye has helped to record tremendous progress for the Nigerian Navy, and all these achievements for our country in less than no time. Adeh is a public affairs analyst based in Gbaramatu.

BOSTON — Forty years ago, Heisman Trophy winner Doug Flutie rolled to his right and threw a pass that has become one of college football’s most iconic moments. With Boston College trailing defending champion Miami, Flutie threw the Hail Mary and found receiver Gerard Phalen, who made the grab while falling into the end zone behind a pair of defenders for a game-winning 48-yard TD. Flutie and many of his 1984 teammates were honored on the field during BC’s 41-21 victory over North Carolina before the second quarter on Saturday afternoon, the anniversary of the Eagles’ Miracle in Miami. “There’s no way its been 40 years,” Flutie told The Associated Press on the sideline a few minutes before he walked out with some of his former teammates to be recognized after a video of The Play was shown on the scoreboards. A statue commemorating Doug Flutie's famed "Hail Mary" pass during a game against Miami on Nov. 23, 1994, sits outside Alumni Stadium at Boston College. Famous football plays often attain a legendary status with religious names like the "Immaculate Reception," the "Hail Mary" pass and the Holy Roller fumble. It’s a moment and highlight that’s not only played throughout decades of BC students and fans, but around the college football world. “What is really so humbling is that the kids 40 years later are wearing 22 jerseys, still,” Flutie said of his old number. “That amazes me.” That game was played on national TV the Friday after Thanksgiving. The ironic thing is it was originally scheduled for earlier in the season before CBS paid Rutgers to move its game against Miami, thus setting up the BC-Miami post-holiday matchup. Boston College quarterback Doug Flutie rejoices in his brother Darren's arms after B.C. defeats Miami with a last second touchdown pass on Nov. 23, 1984, in Miami. “It shows you how random some things are, that the game was moved,” Flutie said. “The game got moved to the Friday after Thanksgiving, which was the most watched game of the year. We both end up being nationally ranked and up there. All those things lent to how big the game itself was, and made the pass and the catch that much more relevant and remembered because so many people were watching.” There’s a statue of Flutie winding up to make The Pass outside the north gates at Alumni Stadium. Fans and visitors can often be seen taking photos there. “In casual conversation, it comes up every day,” Flutie said, when asked how many times people bring it up. “It brings a smile to my face every time we talk about it.” A week after the game-ending Flutie pass, the Eagles beat Holy Cross and before he flew off to New York to accept the Heisman. They went on to win the 49th Cotton Bowl on New Year’s Day. Boston College quarterback Doug Flutie evades Miami defensive tackle Kevin Fagan during the first quarter of a game on Nov. 23, 1984, in Miami, Fla. “Forty years seem almost like incomprehensible,” said Phalen, also standing on the sideline a few minutes after the game started. “I always say to Doug: ‘Thank God for social media. It’s kept it alive for us.”’ Earlier this week, current BC coach Bill O’Brien, 55, was asked if he remembered where he was 40 years ago. “We were eating Thanksgiving leftovers in my family room,” he said. “My mom was saying a Rosary in the kitchen because she didn’t like Miami and wanted BC to win. My dad, my brother and I were watching the game. “It was unbelievable,” he said. “Everybody remembers where they were for the Hail Mary, Flutie pass.” Mike Tyson, left, slaps Jake Paul during a weigh-in ahead of their heavyweight bout, Thursday, Nov. 14, 2024, in Irving, Texas. (AP Photo/Julio Cortez) In this image taken with a slow shutter speed, Spain's tennis player Rafael Nadal serves during a training session at the Martin Carpena Sports Hall, in Malaga, southern Spain, on Friday, Nov. 15, 2024. (AP Photo/Manu Fernandez) A fan takes a picture of the moon prior to a qualifying soccer match for the FIFA World Cup 2026 between Uruguay and Colombia in Montevideo, Uruguay, Friday, Nov. 15, 2024. (AP Photo/Santiago Mazzarovich) Rasmus Højgaard of Denmark reacts after missing a shot on the 18th hole in the final round of World Tour Golf Championship in Dubai, United Arab Emirates, Sunday, Nov. 17, 2024. (AP Photo/Altaf Qadri) Taylor Fritz of the United States reacts during the final match of the ATP World Tour Finals against Italy's Jannik Sinner at the Inalpi Arena, in Turin, Italy, Sunday, Nov. 17, 2024. (AP Photo/Antonio Calanni) Dallas Cowboys wide receiver Jalen Tolbert (1) fails to pull in a pass against Atlanta Falcons cornerback Dee Alford (20) during the second half of an NFL football game, Sunday, Nov. 3, 2024, in Atlanta. (AP Photo/ Brynn Anderson) Green Bay Packers quarterback Jordan Love, top right, scores a touchdown during the second half of an NFL football game against the Chicago Bears in Chicago, Sunday, Nov. 17, 2024. (AP Photo/Nam Y. Huh) India's Tilak Varma jumps in the air as he celebrates after scoring a century during the third T20 International cricket match between South Africa and India, at Centurion Park in Centurion, South Africa, Wednesday, Nov. 13, 2024. (AP Photo/Themba Hadebe) Columbus Blue Jackets defenseman Zach Werenski warms up before facing the Seattle Kraken in an NHL hockey game Tuesday, Nov. 12, 2024, in Seattle. (AP Photo/Lindsey Wasson) Kansas State players run onto the field before an NCAA college football game against Arizona State Saturday, Nov. 16, 2024, in Manhattan, Kan. (AP Photo/Charlie Riedel) A fan rapped in an Uruguay flag arrives to the stands for a qualifying soccer match against Colombia for the FIFA World Cup 2026 in Montevideo, Uruguay, Friday, Nov. 15, 2024. (AP Photo/Matilde Campodonico) People practice folding a giant United States flag before an NFL football game between the Buffalo Bills and the Kansas City Chiefs, Sunday, Nov. 17, 2024, in Orchard Park, N.Y. (AP Photo/Julia Demaree Nikhinson) Brazil's Marquinhos attempts to stop the sprinklers that were turned on during a FIFA World Cup 2026 qualifying soccer match against Venezuela at Monumental stadium in Maturin, Venezuela, Thursday, Nov. 14, 2024. (AP Photo/Ariana Cubillos) Georgia's Georges Mikautadze celebrates after scoring his side's first goal during the UEFA Nations League, group B1 soccer match between Georgia and Ukraine at the AdjaraBet Arena in Batumi, Georgia, Saturday, Nov. 16, 2024. (AP Photo/Tamuna Kulumbegashvili) Dallas Stars center Mavrik Bourque, right, attempts to score while Minnesota Wild right wing Ryan Hartman (38) and Wild goaltender Filip Gustavsson (32) keep the puck out of the net during the second period of an NHL hockey game, Saturday, Nov. 16, 2024, in St. Paul, Minn. (AP Photo/Ellen Schmidt) Mike Tyson, left, fights Jake Paul during their heavyweight boxing match, Friday, Nov. 15, 2024, in Arlington, Texas. (AP Photo/Julio Cortez) Italy goalkeeper Guglielmo Vicario misses the third goal during the Nations League soccer match between Italy and France, at the San Siro stadium in Milan, Italy, Sunday, Nov. 17, 2024. (AP Photo/Luca Bruno) Cincinnati Bengals tight end Mike Gesicki (88) celebrates after scoring a touchdown against the Las Vegas Raiders during the second half of an NFL football game in Cincinnati, Sunday, Nov. 3, 2024. (AP Photo/Carolyn Kaster) President-elect Donald Trump attends UFC 309 at Madison Square Garden, Saturday, Nov. 16, 2024, in New York. (AP Photo/Evan Vucci) Fans argue in stands during the UEFA Nations League soccer match between France and Israel at the Stade de France stadium in Saint-Denis, outside Paris, Thursday Nov. 14, 2024. (AP Photo/Thibault Camus) Slovakia's Rebecca Sramkova hits a return against Danielle Collins, of the United States, during a tennis match at the Billie Jean King Cup Finals at the Martin Carpena Sports Hall, Thursday, Nov. 14, 2024, in Malaga, southern Spain. (AP Photo/Manu Fernandez) St. John's guard RJ Luis Jr. (12) falls after driving to the basket during the second half of an NCAA college basketball game against New Mexico, Sunday, Nov. 17, 2024, in New York. (AP Photo/Pamela Smith) England's Anthony Gordon celebrates after scoring his side's second goal during the UEFA Nations League soccer match between England and the Republic of Ireland at Wembley stadium in London, Sunday, Nov. 17, 2024. (AP Photo/Kin Cheung) Katie Taylor, left, lands a right to Amanda Serrano during their undisputed super lightweight title bout, Friday, Nov. 15, 2024, in Arlington, Texas. (AP Photo/Julio Cortez) Las Vegas Raiders wide receiver DJ Turner, right, tackles Miami Dolphins wide receiver Malik Washington, left, on a punt return during the second half of an NFL football game, Sunday, Nov. 17, 2024, in Miami Gardens, Fla. (AP Photo/Lynne Sladky) UConn's Paige Bueckers (5) battles North Carolina's Laila Hull, right, for a loose ball during the second half of an NCAA college basketball game in Greensboro, N.C., Friday, Nov. 15, 2024. (AP Photo/Ben McKeown) Get local news delivered to your inbox!A man has been charged with doing a Nazi salute at a march in Sydney's inner west after he stepped in front of marchers and allegedly made threatening remarks. or signup to continue reading Police were at an approved gathering in Newtown on Saturday at 2pm, with attendees marching down Victoria Street, in Camperdown, when a 20-year-old not associated with the event stood in front of the procession. NSW Police say he displayed a Nazi salute and made threatening remarks before he was arrested and taken to Newtown Police Station. The man was charged with knowingly displaying a Nazi symbol in public without excuse, and making a Nazi salute gesture in a public place. He was granted strict conditional bail and will appear before Newtown Local Court on January 14. Two of the first people convicted under laws that outlawed shows of Nazi symbolism had their guilty verdicts overturned on Thursday after a judge found their public salutes could not be definitively linked to the fascist German regime. Nikola Marko Gasparovic, 46, Dominik Sieben, 25, and Marijan Lisica, 46, were accused of performing the salute at Parramatta's CommBank Stadium on October 1, 2022 during the Australia Cup final match between Sydney United 58 and Macarthur FC. The convictions of Mr Gasparovic and Mr Seiben were overturned but Judge Sharon Harris upheld the guilty finding against Lisica, who performed the salute seven times. All three were among the first people charged and convicted in NSW under laws that made it a criminal office to knowingly display a Nazi symbol in public without a reasonable excuse. The legislation passed state parliament in August 2022. DAILY Today's top stories curated by our news team. WEEKDAYS Grab a quick bite of today's latest news from around the region and the nation. WEEKLY The latest news, results & expert analysis. WEEKDAYS Catch up on the news of the day and unwind with great reading for your evening. WEEKLY Get the editor's insights: what's happening & why it matters. WEEKLY Love footy? We've got all the action covered. WEEKLY Every Saturday and Tuesday, explore destinations deals, tips & travel writing to transport you around the globe. WEEKLY Going out or staying in? Find out what's on. WEEKDAYS Sharp. Close to the ground. Digging deep. Your weekday morning newsletter on national affairs, politics and more. TWICE WEEKLY Your essential national news digest: all the big issues on Wednesday and great reading every Saturday. WEEKLY Get news, reviews and expert insights every Thursday from CarExpert, ACM's exclusive motoring partner. TWICE WEEKLY Get real, Australia! Let the ACM network's editors and journalists bring you news and views from all over. 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Lions CBs Terrion Arnold, Ennis Rakestraw Jr. out vs. ColtsThe full report can be read in PDF form here . Below is a brief introduction. A pilot study conducted by CDT and Doublethink Lab examines “embedded propaganda” (EP) in African news media. Our study defines EP as the practice of republishing PRC state-media content under a local masthead. This practice is part of the PRC’s external propaganda localization strategy, often referred to as “borrowing a boat to get out to sea” ( 借船出海 ). We sought to track the extent of EP and whether or not it was properly attributed to its source. Focusing on text-based media outlets from Kenya, Uganda, and Ghana during the first 11 months of 2022, we made the following main findings: Our study found 1,203 EP articles across nine outlets in Kenya, Uganda, and Ghana. The majority were published in Uganda’s The Independent (534) and Ghana’s News Ghana (602), and EP comprised a relatively low proportion of the outlets’ total articles. The content of EP articles varied in terms of geographical subject matter, topic, and framing. This included articles both related and unrelated to the PRC and the outlets’ home countries. Most EP news items did not contain a significant pro-PRC bias. The type and consistency of attribution varied among different media outlets. Only a very small number of EP articles (7) failed to properly attribute the PRC state-media source. This is not enough data to provide strong explanatory correlations, but it is more likely that editors were inconsistent or inattentive rather than intentionally deceptive in their choices of re-attribution. The presence of EP articles is cause for concern, insofar as societies depend on citizens informed by transparent and independent media landscapes. As argued by Paul Nantulya , a research associate at the Africa Center for Strategic Studies who focuses on China-Africa relations, “The embedding of CCP media in African media ecosystems risks distorting Africa’s information spaces—and therefore access to independent information shaping citizen debates on a host of issues ranging from governance, society, and the economy.” To the extent that EP permeates African media ecosystems, the narratives that emerge from local information spaces may increasingly resemble PRC narratives rather than genuinely African ones. After all, PRC state media, in contrast to Western news agencies, exists explicitly to serve official interests . It is therefore important to closely track the spread of this phenomenon in order to better understand how to foster resilient and healthy media environments. The findings of our pilot study demonstrate how this methodology can be used for different types of evidence-based monitoring and analysis of EP that we hope can be replicated in future studies at a larger scale. The data has been published by Doublethink Lab and is publicly available on GitHub . The full report can be read here . Categories : CDT Highlights , China & the World , Level 2 Article , Politics , Society Tags : Africa , Africa relations , CGTN , Chinese media , people's daily , state media , Xinhua Related Posts Translation: Anodyne Winners of 34th China Journalism Awards Prompt Declaration That “News is Dead” Chinese Perspectives on the 2024 U.S. Presidential Election China Tightens Grip on Critical Minerals China’s Global Fishing Fleet Intrudes on Distant Waters Translations: “Real Reporters Are Rarer Than Pandas. We Can’t Send Them Off to Clown Around at the Olympics” (3) Sinopsis: How Pro-Russian Narratives Spread in Malaysian Chinese-language Facebook Circles Chinese Investment in Africa Under Scrutiny During FOCAC 2024 Ongoing Deletion of Investigative Reports on Corpse-Trafficking Scandal Mass Censorship of National Corpse Trafficking Scandal Hu Xijin Banned From Weibo for Comments on Private Economy Word of the Week: Garbage Time of History (历史的垃圾时间, lìshǐ de lājī shíjiān) Party Propagandists Promote, Then Backtrack on “Xi as Reformer” Narratives Amid Third Plenum Third Plenum Ends Without Major Announcements Beyond Praise of Xi

AI benefits our society at large in numerous ways, but cybercriminals are using this new technology for nefarious purposes. From gathering data more efficiently to using large language models to craft phishing communications, experienced and novice threat actors are relying on AI to streamline their efforts. Organizations worldwide are taking notice, and executives are implementing efforts to combat this and other shifts in the threat landscape. Sixty-two percent of business leaders say they will mandate cybersecurity training in the form of certifications for IT and security personnel. Nearly as many (61%) say they're introducing new security awareness and training programs for all employees. What to do now to guard against AI-driven threats Malicious actors are increasingly harnessing AI to increase the volume and velocity of attacks they deploy. They are also using this technology to make phishing and related threats more believable than ever. While there are numerous steps your team can take to better protect your organization from these changes in attacker activity, here are five things to do today to make everyone in the enterprise more aware of—and ready to defend against—an increasingly complex threat landscape. 1. Build a culture of cybersecurity Cybersecurity is everyone's job, not just the responsibility of your security and IT teams. Building a culture of cybersecurity within your organization starts with making sure that employees at all levels are aware of common cyber risks and understand the role they play in maintaining robust security. This starts with executives across all departments having a shared vision of cybersecurity and communicating regularly about the importance of safeguarding the enterprise. Other activities should include conducting regular cybersecurity training sessions,... Mamsi NkosiSpecial counsel moves to abandon election interference and classified documents cases against Trump

LET me tell you a story. Login or signup to continue reading A little while ago an unusual shipwreck was thought re-discovered near the mouth of the Hunter River. After drifting sands parted, a scuba diver briefly believed he may have found part of a Spanish shipwreck near Stockton breakwater. Spanish? That seemed highly unlikely, yet much stranger things have happened in the rich maritime history of Newcastle. Such as heavy surf after coastal storms breaking up 19th century colliers sunk deep in Newcastle Bight several times in the 1940s. They then spewed out their coal cargoes to spread like a black carpet along Stockton beach. It was like the sea giving up its dead. But let's return to the reported 'Spanish ship' sunk somewhere near Stockton breakwater. It's now lost again, but truth is often far stranger than fiction. A rare, Spanish-built vessel was indeed sunk in a storm in 1816 at the entrance to Newcastle harbour, a victim of the port's dreaded Oyster Bank (a sand shoal, really). It's exact location, however, is hard to pinpoint, because it could be buried beneath that giant finger of stone extending 3400ft into the ocean we know today as Stockton breakwater. And the whole area there warrants more thorough investigation, according to James Hunter, a senior marine archaeologist with the Australian National Maritime Museum, in Sydney. During a recent talk at the University of Newcastle about Hunter shipwrecks, Hunter said there were almost 300 vessels lost in a relatively small area around the port. "There's a lot of potential here. We've just scratched the surface," he said. His talk was entitled - "More surprises await: Potential for future historic shipwreck archaeology on Newcastle Oyster Bank and surrounds". He said that one of our most interesting wrecks was a Spanish vessel, built in modern-day Ecuador, in South America, and launched over there in October 1803, which had a direct association with Newcastle. This 102-ton armed schooner now known as the Estramina (formerly Extremena) initially undertook hydrographic surveys off the South American coast. It was then mistakenly seized as a British war prize to later spend years trading along the NSW coast before coming to grief off Stockton while leaving Coal (Hunter) River in bad weather. "The Estramina is a very historically significant vessel," Dr Hunter said. "It played a very interesting role, being only one of two known Spanish shipwrecks in Australian waters and the only documented victim of Australian piracy," he said. Dr Hunter said the ship had a busy life. It was even used to evacuate the last convicts and settlers from Norfolk Island when the penal colony there closed in 1814. The Estramina was also caught up in Sydney's notorious 1806 Rum Rebellion, when deposed Governor William Bligh was told to leave the colony, but he baulked at leaving on the ship because of its small size. Dr Hunter said the ship's background was that the Spanish had occupied and controlled South America since the 1500s, but still needed to fully check out its own waters. So it was their vessel (then called Extremena) that was doing survey work when it was attacked off Chile by the armed brig Harrington commanded by Sydney merchant William Campbell. Believing war was imminent between Britain and Spain, Campbell took the opportunity to attack the passing Spanish ship. Although equipped to carry 12 guns, Estramina only carried four x four-pounder cannons and was soon overwhelmed. The crew set her on fire, but this was extinguished and the Spanish ship was taken back to NSW to Jervis Bay. In Sydney, Colonial NSW Governor Philip Gidley King, fearing a major international incident, ordered the Spanish ship detained. After all, Campbell had been accused of being heavily involved with illegal trading in South America. War did finally break out, so the ship was then sold at auction with the NSW colonial government successfully buying her for 21,000 pounds and renaming her Estramina. The vessel came to Newcastle in January 1816, but, while attempting to leave port with a cargo of coal and timber, she sank. The Estramina's anchor chain parted, and she ran aground on the Oyster Bank where she broke up fairly quickly, settling in the sand and disappearing. Dr Hunter said that, luckily, an 1816 chart then identified where the wreck should be, but an overlay of this map with a modern chart indicated it could be buried beneath Stockton breakwater. "It might be there, but you don't know until you look," Dr Hunter said. The shipwreck hunter said a normal method of detecting iron objects underwater, such as anchor chains or even old guns carried as ballast, by using a magnetometer, would be futile. "The Stockton breakwater was completed in 1912, but what might not be known is that it is predominantly built on (metal) shipwrecks," he said. Dr Hunter added that even known shipwreck sites, such as at Stockton breakwater, could be confusing, speculating there might be yet more unknown wrecks beneath those already identified. He might be right. Well, it may be just a co-incidence, but there was the discovery of an unidentified shipwreck in roughly that same area about 40 years ago. Largely unreported at the time, it seemed to have never been seriously followed up by anyone, possibly because of shifting sand smothering the site and one of the divers involved moving interstate. In the 1980s, two recreational divers said they had stumbled on three, possibly four, mystery guns buried in sand in a shipwreck on the edge of a Newcastle breakwater. The three guns were found by accident in about 15 metres of murky water while the divers were looking for another wreck. The divers, both keen shipwreck enthusiasts, were flabbergasted by the find. They believed no other Hunter district wreck had ever been found to be carrying cannons. One small iron cannon recovered was believed to be possibly a signal gun. The short muzzle loader might also be a swivel gun normally mounted on a ship's rail and used to repel boarders at close range with a shotgun-like blast. The gun, measuring about a metre, had no visible markings and was pitted and corroded in parts but the barrel was otherwise in remarkable condition. According to one of the divers, the swivel cannon was taken to Sydney for treatment, including electrolysis, to try to arrest the corrosion before the object was to be returned to Newcastle. The diver described the 'swivel gun' as having "a 3 1/2 inch diameter and weighing about 120 lbs". It had trunnions (knobs) with rusted iron in them, indicating side supports to allow it to swivel upright. More intriguingly, the divers claimed to have found a much bigger, buried gun, at least 120 years old, measuring "four to five feet long and weighing maybe 400-500 pounds". "(But) there's at least another cannon, maybe two down there," the diver said. The big gun was sticking up between ship timber ribs and ballast. The wreck was more than 13 metres long. At the time, Stockton maritime historian Terry Callen said cannons went out of fashion after the 1850s but were used by traders in the South China seas that were full of pirates. DAILY Today's top stories curated by our news team. Also includes evening update. WEEKDAYS Grab a quick bite of today's latest news from around the region and the nation. WEEKLY The latest news, results & expert analysis. WEEKDAYS Catch up on the news of the day and unwind with great reading for your evening. WEEKLY Get the editor's insights: what's happening & why it matters. WEEKLY Love footy? We've got all the action covered. WEEKLY Every Saturday and Tuesday, explore destinations deals, tips & travel writing to transport you around the globe. WEEKLY Get the latest property and development news here. WEEKLY Going out or staying in? Find out what's on. WEEKDAYS Sharp. Close to the ground. Digging deep. Your weekday morning newsletter on national affairs, politics and more. WEEKLY Follow the Newcastle Knights in the NRL? Don't miss your weekly Knights update. TWICE WEEKLY Your essential national news digest: all the big issues on Wednesday and great reading every Saturday. WEEKLY Get news, reviews and expert insights every Thursday from CarExpert, ACM's exclusive motoring partner. TWICE WEEKLY Get real, Australia! Let the ACM network's editors and journalists bring you news and views from all over. AS IT HAPPENS Be the first to know when news breaks. DAILY Your digital replica of Today's Paper. Ready to read from 5am! DAILY Test your skills with interactive crosswords, sudoku & trivia. Fresh daily!Kellyanne Conway Confronted Meghan McCain at Women’s Power Summit